SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development

Research output: Contribution to journalArticlepeer-review

Authors

  • Rutger L. Van Bezooijen
  • Marco C. DeRuiter
  • Nathalie Vilain
  • Annemieke Visser
  • Lianne Van Der Wee-Pals
  • Conny J. Van Munsteren
  • Paneras C.W. Hogendoorn
  • Michel Aguet
  • Christine L. Mummery
  • Socrates E. Papapoulos
  • Peter Ten Dijke
  • Clemens W.G.M. Löwik

Colleges, School and Institutes

External organisations

  • Leiden University Medical Center - LUMC
  • Swiss Institute for Experimental Cancer Research
  • Hubrecht Laboratory KNAW (Netherlands Institute for Developmental Biology)

Abstract

Spatial-temporal regulation of bone morphogenetic protein (BMP) and Wnt activity is essential for normal cardiovascular development, and altered activity of these growth factors causes maldevelopment of the cardiac outflow tract and great arteries. In the present study, we show that SOST, a Dan family member reported to antagonize BMP and Wnt activity, is expressed within the medial vessel wall of the great arteries containing smooth muscle cells. The ascending aorta, aortic arch, brachiocephalic artery, common carotids, and pulmonary trunk were all associated with SOST expressing smooth muscle cells, while the heart itself, including the valves, and more distal arteries, that is, pulmonary arteries, subclavian arteries, and descending aorta, were negative. SOST was expressed from embryonic day 15.5 up to the neonatal period. SOST expression, however, did not correspond with inhibition of Smad-dependent BMP activity or β-catenin-dependent Wnt activity in the great arteries. Activity of both signaling pathways was already down-regulated before induction of SOST expression.

Details

Original languageEnglish
Pages (from-to)606-612
Number of pages7
JournalDevelopmental Dynamics
Volume236
Issue number2
Publication statusPublished - 1 Feb 2007

Keywords

  • BMP, Great arteries, Heart development, Outflow tract, SOST, Wnt

ASJC Scopus subject areas