Sorafenib for older patients with renal cell carcinoma: subset analysis from a randomized trial

T Eisen; S Oudard; C Szczylik; G Gravis; H Heinzer; R Middleton; F Cihon; S Anderson; S Shah; R Bukowski; B Escudier; Emilio Porfiri; Target Study group

doi:10.1093/jnci/djn319

Sorafenib for older patients with renal cell carcinoma: subset analysis from a randomized trial

T Eisen, S Oudard, C Szczylik, G Gravis, H Heinzer, R Middleton, F Cihon, S Anderson, S Shah, R Bukowski, B Escudier, Emilio Porfiri, Target Study group

Cancer Clinical Trials Unit

Research output: Contribution to journal › Article

118 Citations (Scopus)

Abstract

BACKGROUND: The perception that older cancer patients may be at higher risk than younger patients of toxic effects from cancer therapy but may obtain less clinical benefit from it may be based on the underrepresentation of older patients in clinical trials and the known toxic effects of cytotoxic chemotherapy. It is not known how older patients respond to targeted therapy. METHODS: This retrospective subgroup analysis of data from the phase 3, randomized Treatment Approach in Renal Cancer Global Evaluation Trial examined the safety and efficacy of sorafenib in older (age >or=70 years, n = 115) and younger patients (age or=70 years) and younger (

Original language	English
Pages (from-to)	1454-63
Number of pages	10
Journal	Journal of the National Cancer Institute
Volume	100
Issue number	20
DOIs	https://doi.org/10.1093/jnci/djn319
Publication status	Published - 15 Oct 2008

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Eisen, T., Oudard, S., Szczylik, C., Gravis, G., Heinzer, H., Middleton, R., Cihon, F., Anderson, S., Shah, S., Bukowski, R., Escudier, B., Porfiri, E., & Target Study group (2008). Sorafenib for older patients with renal cell carcinoma: subset analysis from a randomized trial. Journal of the National Cancer Institute, 100(20), 1454-63. https://doi.org/10.1093/jnci/djn319

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abstract = "BACKGROUND: The perception that older cancer patients may be at higher risk than younger patients of toxic effects from cancer therapy but may obtain less clinical benefit from it may be based on the underrepresentation of older patients in clinical trials and the known toxic effects of cytotoxic chemotherapy. It is not known how older patients respond to targeted therapy. METHODS: This retrospective subgroup analysis of data from the phase 3, randomized Treatment Approach in Renal Cancer Global Evaluation Trial examined the safety and efficacy of sorafenib in older (age >or=70 years, n = 115) and younger patients (age or=70 years) and younger (",

author = "T Eisen and S Oudard and C Szczylik and G Gravis and H Heinzer and R Middleton and F Cihon and S Anderson and S Shah and R Bukowski and B Escudier and Emilio Porfiri and {Target Study group}",

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doi = "10.1093/jnci/djn319",

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Eisen, T, Oudard, S, Szczylik, C, Gravis, G, Heinzer, H, Middleton, R, Cihon, F, Anderson, S, Shah, S, Bukowski, R, Escudier, B, Porfiri, E & Target Study group 2008, 'Sorafenib for older patients with renal cell carcinoma: subset analysis from a randomized trial', Journal of the National Cancer Institute, vol. 100, no. 20, pp. 1454-63. https://doi.org/10.1093/jnci/djn319

TY - JOUR

T1 - Sorafenib for older patients with renal cell carcinoma: subset analysis from a randomized trial

AU - Eisen, T

AU - Oudard, S

AU - Szczylik, C

AU - Gravis, G

AU - Heinzer, H

AU - Middleton, R

AU - Cihon, F

AU - Anderson, S

AU - Shah, S

AU - Bukowski, R

AU - Escudier, B

AU - Porfiri, Emilio

AU - Target Study group

PY - 2008/10/15

Y1 - 2008/10/15

N2 - BACKGROUND: The perception that older cancer patients may be at higher risk than younger patients of toxic effects from cancer therapy but may obtain less clinical benefit from it may be based on the underrepresentation of older patients in clinical trials and the known toxic effects of cytotoxic chemotherapy. It is not known how older patients respond to targeted therapy. METHODS: This retrospective subgroup analysis of data from the phase 3, randomized Treatment Approach in Renal Cancer Global Evaluation Trial examined the safety and efficacy of sorafenib in older (age >or=70 years, n = 115) and younger patients (age or=70 years) and younger (

AB - BACKGROUND: The perception that older cancer patients may be at higher risk than younger patients of toxic effects from cancer therapy but may obtain less clinical benefit from it may be based on the underrepresentation of older patients in clinical trials and the known toxic effects of cytotoxic chemotherapy. It is not known how older patients respond to targeted therapy. METHODS: This retrospective subgroup analysis of data from the phase 3, randomized Treatment Approach in Renal Cancer Global Evaluation Trial examined the safety and efficacy of sorafenib in older (age >or=70 years, n = 115) and younger patients (age or=70 years) and younger (

U2 - 10.1093/jnci/djn319

DO - 10.1093/jnci/djn319

M3 - Article

C2 - 18840822

SN - 1460-2105

VL - 100

SP - 1454

EP - 1463

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 20

ER -

Sorafenib for older patients with renal cell carcinoma: subset analysis from a randomized trial

Abstract

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