Sonication-microfluidics for fabrication of nanoparticle-stabilized microbubbles

Research output: Contribution to journalArticlepeer-review


  • Haosheng Chen
  • Jiang Li
  • Weizheng Zhou
  • Simeon D. Stoyanov
  • Luben N. Arnaudov
  • Howard A. Stone

Colleges, School and Institutes


An approach based upon sonication-microfluidics is presented to fabricate nanoparticle-coated microbubbles. The gas-in-liquid slug flow formed in a microchannel is subjected to ultrasound, leading to cavitation at the gas-liquid interface. Therefore, microbubbles are formed and then stabilized by the nanoparticles contained in the liquid. Compared to the conventional sonication method, this sonication-microfluidics continuous flow approach has unlimited gas nuclei for cavitation that yields continuous production of foam with shorter residence time. By controlling the flow rate ratios of the gas to the liquid, this method also achieves a higher production volume, smaller bubble size, and less waste of the nanoparticles needed to stabilize the microbubbles.


Original languageEnglish
Pages (from-to)4262-4266
Number of pages5
Issue number15
Publication statusPublished - 2 Apr 2014