Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortality

Research output: Contribution to journalArticle

Authors

  • H W Zimmermann
  • P A Reuken
  • A Koch
  • M Bartneck
  • D H Adams
  • C Trautwein
  • A Stallmach
  • F Tacke
  • T Bruns

Abstract

Patients with decompensated cirrhosis are susceptible to bacterial infections, which are associated with organ failure and a high mortality rate. Reliable biomarkers are needed to identify patients who require intensified treatment. Our objective was to study the regulation and prognostic relevance of elevated concentrations of soluble urokinase plasminogen activator receptor (suPAR) in patients with advanced cirrhosis.

Bibliographic note

© 2013 The Association for the Publication of the Journal of Internal Medicine.

Details

Original languageEnglish
Pages (from-to)86-100
Number of pages15
JournalJournal of Internal Medicine
Volume274
Issue number1
Publication statusPublished - Jul 2013

Keywords

  • Adult, Aged, Aged, 80 and over, Analysis of Variance, Ascitic Fluid, Bacterial Infections, Biological Markers, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Escherichia coli Infections, Female, Germany, Humans, Liver, Liver Cirrhosis, Male, Middle Aged, Odds Ratio, Paracentesis, Predictive Value of Tests, Prognosis, Prospective Studies, Receptors, Urokinase Plasminogen Activator, Risk Assessment, Risk Factors, Severity of Illness Index