Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortality
Research output: Contribution to journal › Article
Authors
Colleges, School and Institutes
Abstract
Patients with decompensated cirrhosis are susceptible to bacterial infections, which are associated with organ failure and a high mortality rate. Reliable biomarkers are needed to identify patients who require intensified treatment. Our objective was to study the regulation and prognostic relevance of elevated concentrations of soluble urokinase plasminogen activator receptor (suPAR) in patients with advanced cirrhosis.
Bibliographic note
© 2013 The Association for the Publication of the Journal of Internal Medicine.
Details
| Original language | English |
|---|---|
| Pages (from-to) | 86-100 |
| Number of pages | 15 |
| Journal | Journal of Internal Medicine |
| Volume | 274 |
| Issue number | 1 |
| Publication status | Published - Jul 2013 |
Keywords
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Ascitic Fluid, Bacterial Infections, Biological Markers, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Escherichia coli Infections, Female, Germany, Humans, Liver, Liver Cirrhosis, Male, Middle Aged, Odds Ratio, Paracentesis, Predictive Value of Tests, Prognosis, Prospective Studies, Receptors, Urokinase Plasminogen Activator, Risk Assessment, Risk Factors, Severity of Illness Index