Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortality

H W Zimmermann; P A Reuken; A Koch; M Bartneck; C Trautwein; A Stallmach; F Tacke; T Bruns; David Adams

doi:10.1111/joim.12054

Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortality

H W Zimmermann, P A Reuken, A Koch, M Bartneck, C Trautwein, A Stallmach, F Tacke, T Bruns, David Adams

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Patients with decompensated cirrhosis are susceptible to bacterial infections, which are associated with organ failure and a high mortality rate. Reliable biomarkers are needed to identify patients who require intensified treatment. Our objective was to study the regulation and prognostic relevance of elevated concentrations of soluble urokinase plasminogen activator receptor (suPAR) in patients with advanced cirrhosis.

Original language	English
Pages (from-to)	86-100
Number of pages	15
Journal	Journal of Internal Medicine
Volume	274
Issue number	1
DOIs	https://doi.org/10.1111/joim.12054
Publication status	Published - Jul 2013

Bibliographical note

Keywords

Adult
Aged
Aged, 80 and over
Analysis of Variance
Ascitic Fluid
Bacterial Infections
Biological Markers
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Escherichia coli Infections
Female
Germany
Humans
Liver
Liver Cirrhosis
Male
Middle Aged
Odds Ratio
Paracentesis
Predictive Value of Tests
Prognosis
Prospective Studies
Receptors, Urokinase Plasminogen Activator
Risk Assessment
Risk Factors
Severity of Illness Index

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10.1111/joim.12054

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Zimmermann, H. W., Reuken, P. A., Koch, A., Bartneck, M., Trautwein, C., Stallmach, A., Tacke, F., Bruns, T., & Adams, D. (2013). Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortality. Journal of Internal Medicine, 274(1), 86-100. https://doi.org/10.1111/joim.12054

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title = "Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortality",

abstract = "Patients with decompensated cirrhosis are susceptible to bacterial infections, which are associated with organ failure and a high mortality rate. Reliable biomarkers are needed to identify patients who require intensified treatment. Our objective was to study the regulation and prognostic relevance of elevated concentrations of soluble urokinase plasminogen activator receptor (suPAR) in patients with advanced cirrhosis.",

keywords = "Adult, Aged, Aged, 80 and over, Analysis of Variance, Ascitic Fluid, Bacterial Infections, Biological Markers, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Escherichia coli Infections, Female, Germany, Humans, Liver, Liver Cirrhosis, Male, Middle Aged, Odds Ratio, Paracentesis, Predictive Value of Tests, Prognosis, Prospective Studies, Receptors, Urokinase Plasminogen Activator, Risk Assessment, Risk Factors, Severity of Illness Index",

author = "Zimmermann, {H W} and Reuken, {P A} and A Koch and M Bartneck and C Trautwein and A Stallmach and F Tacke and T Bruns and David Adams",

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Zimmermann, HW, Reuken, PA, Koch, A, Bartneck, M, Trautwein, C, Stallmach, A, Tacke, F, Bruns, T & Adams, D 2013, 'Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortality', Journal of Internal Medicine, vol. 274, no. 1, pp. 86-100. https://doi.org/10.1111/joim.12054

TY - JOUR

T1 - Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortality

AU - Zimmermann, H W

AU - Reuken, P A

AU - Koch, A

AU - Bartneck, M

AU - Trautwein, C

AU - Stallmach, A

AU - Tacke, F

AU - Bruns, T

AU - Adams, David

PY - 2013/7

Y1 - 2013/7

N2 - Patients with decompensated cirrhosis are susceptible to bacterial infections, which are associated with organ failure and a high mortality rate. Reliable biomarkers are needed to identify patients who require intensified treatment. Our objective was to study the regulation and prognostic relevance of elevated concentrations of soluble urokinase plasminogen activator receptor (suPAR) in patients with advanced cirrhosis.

AB - Patients with decompensated cirrhosis are susceptible to bacterial infections, which are associated with organ failure and a high mortality rate. Reliable biomarkers are needed to identify patients who require intensified treatment. Our objective was to study the regulation and prognostic relevance of elevated concentrations of soluble urokinase plasminogen activator receptor (suPAR) in patients with advanced cirrhosis.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Analysis of Variance

KW - Ascitic Fluid

KW - Bacterial Infections

KW - Biological Markers

KW - Case-Control Studies

KW - Enzyme-Linked Immunosorbent Assay

KW - Escherichia coli Infections

KW - Female

KW - Germany

KW - Humans

KW - Liver

KW - Liver Cirrhosis

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Paracentesis

KW - Predictive Value of Tests

KW - Prognosis

KW - Prospective Studies

KW - Receptors, Urokinase Plasminogen Activator

KW - Risk Assessment

KW - Risk Factors

KW - Severity of Illness Index

U2 - 10.1111/joim.12054

DO - 10.1111/joim.12054

M3 - Article

C2 - 23432143

SN - 0954-6820

VL - 274

SP - 86

EP - 100

JO - Journal of Internal Medicine

JF - Journal of Internal Medicine

IS - 1

ER -

Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short-term mortality

Abstract

Bibliographical note

Keywords

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