Soluble E-selectin in cardiovascular disease and its risk factors. A review of the literature

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Soluble E-selectin in cardiovascular disease and its risk factors. A review of the literature. / Roldan, V; Marin, F; Lip, Gregory; Blann, Andrew.

In: Thrombosis and Haemostasis, Vol. 90, No. 6, 01.12.2003, p. 1007-20.

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@article{c1384e92c93c49dd8c6491e29d563683,
title = "Soluble E-selectin in cardiovascular disease and its risk factors. A review of the literature",
abstract = "The initial steps in the pathogenesis of atherosclerosis involve changes to the vascular endothelium, which produces numerous substances involved in the regulation and maintenance of vascular integrity and the homeostasis of the coagulation/fibrinolysis system. A further change in endothelial physiology is an increase in the surface expression of cell adhesion molecules, such as E-selectin, which regulate adhesive interactions between certain blood cells and endothelium. As E-selectin is only expressed on activated endothelium, it therefore provides an opportunity to study pathophysiological aspects of this cell in cardiovascular and other disease. However, a soluble form of E selectin (i.e. sE-selectin) can be found in the plasma. This review will focus on sE-selectin, and its potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial.",
author = "V Roldan and F Marin and Gregory Lip and Andrew Blann",
year = "2003",
month = dec,
day = "1",
doi = "10.1267/THRO03061007",
language = "English",
volume = "90",
pages = "1007--20",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "Schattauer",
number = "6",

}

RIS

TY - JOUR

T1 - Soluble E-selectin in cardiovascular disease and its risk factors. A review of the literature

AU - Roldan, V

AU - Marin, F

AU - Lip, Gregory

AU - Blann, Andrew

PY - 2003/12/1

Y1 - 2003/12/1

N2 - The initial steps in the pathogenesis of atherosclerosis involve changes to the vascular endothelium, which produces numerous substances involved in the regulation and maintenance of vascular integrity and the homeostasis of the coagulation/fibrinolysis system. A further change in endothelial physiology is an increase in the surface expression of cell adhesion molecules, such as E-selectin, which regulate adhesive interactions between certain blood cells and endothelium. As E-selectin is only expressed on activated endothelium, it therefore provides an opportunity to study pathophysiological aspects of this cell in cardiovascular and other disease. However, a soluble form of E selectin (i.e. sE-selectin) can be found in the plasma. This review will focus on sE-selectin, and its potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial.

AB - The initial steps in the pathogenesis of atherosclerosis involve changes to the vascular endothelium, which produces numerous substances involved in the regulation and maintenance of vascular integrity and the homeostasis of the coagulation/fibrinolysis system. A further change in endothelial physiology is an increase in the surface expression of cell adhesion molecules, such as E-selectin, which regulate adhesive interactions between certain blood cells and endothelium. As E-selectin is only expressed on activated endothelium, it therefore provides an opportunity to study pathophysiological aspects of this cell in cardiovascular and other disease. However, a soluble form of E selectin (i.e. sE-selectin) can be found in the plasma. This review will focus on sE-selectin, and its potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial.

UR - http://www.scopus.com/inward/record.url?scp=0348163668&partnerID=8YFLogxK

U2 - 10.1267/THRO03061007

DO - 10.1267/THRO03061007

M3 - Review article

C2 - 14652631

VL - 90

SP - 1007

EP - 1020

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 6

ER -