Solubility of Azoxystrobin and Benflumetol in compressed CO2 - measured by the static precise mass measuring method

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Colleges, School and Institutes

External organisations

  • Guangzhou University of Chinese Medicine
  • Birmingham University
  • Centre for Formulation Engineering
  • Interdisciplinary Research Centre


The solubilities of hardly soluble solutes in compressed CO2 were measured using a new static precise mass measuring (SPMM) method. The solubilities of two solutes - azoxystrobin, a substituted pyrimidine, and benflumetol, an antimalarial drug - were determined at pressures and temperatures from 80 to 250 bar and 301 to 323 K. The solubilities of these two compounds were 64-661 and 1.3-19.7 mg/kg of CO2, respectively. The measured solubilities were correlated using the density-based model proposed by Chrastil and the theory of dilute solutions-based model proposed by Mendez-Santiago and Teja. A linear relationship between the solubility and the solvent density was obtained.


Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalJournal of Chemical and Engineering Data
Issue number1
Early online date20 Dec 2018
Publication statusE-pub ahead of print - 20 Dec 2018