Solubilities of Pharmaceutical Compounds in Ionic Liquids

KB Smith; Rachel Bridson; Gary Leeke

doi:10.1021/je101040p

Solubilities of Pharmaceutical Compounds in Ionic Liquids

KB Smith, Rachel Bridson, Gary Leeke

Chemical Engineering

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Abstract

The solubilities of paracetamol and ibuprofen were determined in two different ionic liquids at temperatures of 298.15 K, 308.15 K, 318.15 K, 328.15 K, and 338.15 K. The ionic liquids selected were 1-butyl-3-methylimidazolium hexafluorophosphate [BMIM][PF6] and 1-hexyl-3-methylimidazolium hexafluorophosphate [HMIM][PF6]. In addition, solubility data for paracetamol and ibuprofen in water are reported at the same temperatures extending the data commonly reported in pharmaceutical reference texts. For all solvents the concentration of drug in solution was determined by UV spectrophotometry.

Original language	English
Pages (from-to)	2039–2043
Journal	Journal of Chemical Engineering Data
Volume	56
Issue number	5
DOIs	https://doi.org/10.1021/je101040p
Publication status	Published - 1 Jan 2009

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http://pubs.acs.org/doi/abs/10.1021/je101040p

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title = "Solubilities of Pharmaceutical Compounds in Ionic Liquids",

abstract = "The solubilities of paracetamol and ibuprofen were determined in two different ionic liquids at temperatures of 298.15 K, 308.15 K, 318.15 K, 328.15 K, and 338.15 K. The ionic liquids selected were 1-butyl-3-methylimidazolium hexafluorophosphate [BMIM][PF6] and 1-hexyl-3-methylimidazolium hexafluorophosphate [HMIM][PF6]. In addition, solubility data for paracetamol and ibuprofen in water are reported at the same temperatures extending the data commonly reported in pharmaceutical reference texts. For all solvents the concentration of drug in solution was determined by UV spectrophotometry. ",

author = "KB Smith and Rachel Bridson and Gary Leeke",

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AU - Bridson, Rachel

AU - Leeke, Gary

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N2 - The solubilities of paracetamol and ibuprofen were determined in two different ionic liquids at temperatures of 298.15 K, 308.15 K, 318.15 K, 328.15 K, and 338.15 K. The ionic liquids selected were 1-butyl-3-methylimidazolium hexafluorophosphate [BMIM][PF6] and 1-hexyl-3-methylimidazolium hexafluorophosphate [HMIM][PF6]. In addition, solubility data for paracetamol and ibuprofen in water are reported at the same temperatures extending the data commonly reported in pharmaceutical reference texts. For all solvents the concentration of drug in solution was determined by UV spectrophotometry.

AB - The solubilities of paracetamol and ibuprofen were determined in two different ionic liquids at temperatures of 298.15 K, 308.15 K, 318.15 K, 328.15 K, and 338.15 K. The ionic liquids selected were 1-butyl-3-methylimidazolium hexafluorophosphate [BMIM][PF6] and 1-hexyl-3-methylimidazolium hexafluorophosphate [HMIM][PF6]. In addition, solubility data for paracetamol and ibuprofen in water are reported at the same temperatures extending the data commonly reported in pharmaceutical reference texts. For all solvents the concentration of drug in solution was determined by UV spectrophotometry.

U2 - 10.1021/je101040p

DO - 10.1021/je101040p

M3 - Article

VL - 56

SP - 2039

EP - 2043

JO - Journal of Chemical Engineering Data

JF - Journal of Chemical Engineering Data

IS - 5

ER -

Solubilities of Pharmaceutical Compounds in Ionic Liquids

Abstract

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