Soft tissue deposit in neck dissection specimen carries a poor prognosis in oral cancer: a matched pair analysis

Akshat Malik; Sudhir Nair; Arjun Singh; Komal Lamba; Swapnil Rane; Munita Bal; Atanu Bhattacharjee; Hisham Mehanna; Pankaj Chaturvedi

doi:10.1002/hed.26103

Soft tissue deposit in neck dissection specimen carries a poor prognosis in oral cancer: a matched pair analysis

Akshat Malik, Sudhir Nair^*, Arjun Singh, Komal Lamba, Swapnil Rane, Munita Bal, Atanu Bhattacharjee, Hisham Mehanna, Pankaj Chaturvedi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background: Soft tissue deposit (STD) is the presence of tumor foci in the neck at sites other than lymphoid tissue. We evaluated the factors associated with STD and their impact on outcomes.

Methods: The records of 4812 treatment naïve oral cancers operated between December 2010 and September 2015 were screened for the presence of STD. A matched-pair analysis was performed to obtain 450 patients without STD. Chi-square was used to test association with clinicopathological factors and hazard ratio (HR) for overall survival (OS) and disease-free survival (DFS) were calculated.

Results: STD was present in 0.6% and associated with gingiva-buccal cancers, advanced stage, poor differentiation, presence of extranodal extension (ENE) and higher locoregional/distant metastasis. They had a significantly poorer OS (HR-2.08; P-value.0073) and DFS (HR-2.5; P-value.0002) with and without ENE [HR-1.96 and 3.7, respectively].

Conclusion: Despite aggressive adjuvant therapy STD has a significant negative impact on outcomes.

Original language	English
Pages (from-to)	1783-1790
Journal	Head and Neck
Volume	42
Issue number	8
Early online date	11 Feb 2020
DOIs	https://doi.org/10.1002/hed.26103
Publication status	E-pub ahead of print - 11 Feb 2020

Keywords

neck dissection
oral cancer
soft tissue deposit
STD
tumor deposit

ASJC Scopus subject areas

Otorhinolaryngology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Soft tissue deposit in neck dissection specimen carries a poor prognosis in oral cancer: a matched pair analysis",

abstract = "Background: Soft tissue deposit (STD) is the presence of tumor foci in the neck at sites other than lymphoid tissue. We evaluated the factors associated with STD and their impact on outcomes. Methods: The records of 4812 treatment na{\"i}ve oral cancers operated between December 2010 and September 2015 were screened for the presence of STD. A matched-pair analysis was performed to obtain 450 patients without STD. Chi-square was used to test association with clinicopathological factors and hazard ratio (HR) for overall survival (OS) and disease-free survival (DFS) were calculated. Results: STD was present in 0.6% and associated with gingiva-buccal cancers, advanced stage, poor differentiation, presence of extranodal extension (ENE) and higher locoregional/distant metastasis. They had a significantly poorer OS (HR-2.08; P-value.0073) and DFS (HR-2.5; P-value.0002) with and without ENE [HR-1.96 and 3.7, respectively]. Conclusion: Despite aggressive adjuvant therapy STD has a significant negative impact on outcomes.",

keywords = "neck dissection, oral cancer, soft tissue deposit, STD, tumor deposit",

author = "Akshat Malik and Sudhir Nair and Arjun Singh and Komal Lamba and Swapnil Rane and Munita Bal and Atanu Bhattacharjee and Hisham Mehanna and Pankaj Chaturvedi",

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T1 - Soft tissue deposit in neck dissection specimen carries a poor prognosis in oral cancer

T2 - a matched pair analysis

AU - Malik, Akshat

AU - Nair, Sudhir

AU - Singh, Arjun

AU - Lamba, Komal

AU - Rane, Swapnil

AU - Bal, Munita

AU - Bhattacharjee, Atanu

AU - Mehanna, Hisham

AU - Chaturvedi, Pankaj

PY - 2020/2/11

Y1 - 2020/2/11

N2 - Background: Soft tissue deposit (STD) is the presence of tumor foci in the neck at sites other than lymphoid tissue. We evaluated the factors associated with STD and their impact on outcomes. Methods: The records of 4812 treatment naïve oral cancers operated between December 2010 and September 2015 were screened for the presence of STD. A matched-pair analysis was performed to obtain 450 patients without STD. Chi-square was used to test association with clinicopathological factors and hazard ratio (HR) for overall survival (OS) and disease-free survival (DFS) were calculated. Results: STD was present in 0.6% and associated with gingiva-buccal cancers, advanced stage, poor differentiation, presence of extranodal extension (ENE) and higher locoregional/distant metastasis. They had a significantly poorer OS (HR-2.08; P-value.0073) and DFS (HR-2.5; P-value.0002) with and without ENE [HR-1.96 and 3.7, respectively]. Conclusion: Despite aggressive adjuvant therapy STD has a significant negative impact on outcomes.

AB - Background: Soft tissue deposit (STD) is the presence of tumor foci in the neck at sites other than lymphoid tissue. We evaluated the factors associated with STD and their impact on outcomes. Methods: The records of 4812 treatment naïve oral cancers operated between December 2010 and September 2015 were screened for the presence of STD. A matched-pair analysis was performed to obtain 450 patients without STD. Chi-square was used to test association with clinicopathological factors and hazard ratio (HR) for overall survival (OS) and disease-free survival (DFS) were calculated. Results: STD was present in 0.6% and associated with gingiva-buccal cancers, advanced stage, poor differentiation, presence of extranodal extension (ENE) and higher locoregional/distant metastasis. They had a significantly poorer OS (HR-2.08; P-value.0073) and DFS (HR-2.5; P-value.0002) with and without ENE [HR-1.96 and 3.7, respectively]. Conclusion: Despite aggressive adjuvant therapy STD has a significant negative impact on outcomes.

KW - neck dissection

KW - oral cancer

KW - soft tissue deposit

KW - STD

KW - tumor deposit

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DO - 10.1002/hed.26103

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JO - Head and Neck

JF - Head and Neck

IS - 8

ER -

Soft tissue deposit in neck dissection specimen carries a poor prognosis in oral cancer: a matched pair analysis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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