Soft, adhesive (+) alpha tocopherol phosphate planar bilayers that control oral biofilm growth through a substantive antimicrobial effect

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Soft, adhesive (+) alpha tocopherol phosphate planar bilayers that control oral biofilm growth through a substantive antimicrobial effect. / Harper, Robert; Saleh, Mais M; Carpenter, Guy; Abbate, Vincenzo; Proctor, Gordon; Harvey, Richard D ; Gambogi, Robert J; Geonnotti, Anthony; Hider, Robert; Jones, Stuart A.

In: Nanomedicine: Nanotechnology, Biology and Medicine, 02.02.2018.

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Harper, Robert ; Saleh, Mais M ; Carpenter, Guy ; Abbate, Vincenzo ; Proctor, Gordon ; Harvey, Richard D ; Gambogi, Robert J ; Geonnotti, Anthony ; Hider, Robert ; Jones, Stuart A. / Soft, adhesive (+) alpha tocopherol phosphate planar bilayers that control oral biofilm growth through a substantive antimicrobial effect. In: Nanomedicine: Nanotechnology, Biology and Medicine. 2018.

Bibtex

@article{c7364cbc9f254c43baf2635f7bdbdd63,
title = "Soft, adhesive (+) alpha tocopherol phosphate planar bilayers that control oral biofilm growth through a substantive antimicrobial effect",
abstract = "{\textquoteleft}Soft{\textquoteright} nanomaterials have the potential to produce substantive antibiofilm effects. The aim of this study was to understand the oral antimicrobial activity of soft nanomaterials generated from alpha-tocopherol (α-T) and alpha-tocopherol phosphate (α-TP). (+) α-TP formed planar bilayer islands (175 ± 21 nm, −14.9 ± 3.5 mV) in a Trizma{\textregistered} buffer, whereas (+) α-T formed spherical liposomes (563 ± 1 nm, −10.5 ± 0.2 mV). The (+) α-TP bilayers displayed superior Streptococcus oralis biofilm growth retardation, a more substantive action, generated a superior adsorption to hydroxyapatite and showed an enhanced inhibition of multi-species bacterial saliva biofilm growth (38 ± 7μm vs 58 ± 18 μm, P ˂ 0.05) compared to (+) α-T. Atomic force microscopy data indicated that the ability of the {\textquoteleft}soft{\textquoteright} α-TP nanomaterials to transition into planar bilayer structures upon contact with interfaces facilitated their adhesive properties and substantive antimicrobial effects.",
author = "Robert Harper and Saleh, {Mais M} and Guy Carpenter and Vincenzo Abbate and Gordon Proctor and Harvey, {Richard D} and Gambogi, {Robert J} and Anthony Geonnotti and Robert Hider and Jones, {Stuart A}",
year = "2018",
month = feb,
day = "2",
doi = "10.1016/j.nano.2017.12.024",
language = "English",
journal = "Nanomedicine: Nanotechnology, Biology and Medicine",
issn = "1549-9634",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Soft, adhesive (+) alpha tocopherol phosphate planar bilayers that control oral biofilm growth through a substantive antimicrobial effect

AU - Harper, Robert

AU - Saleh, Mais M

AU - Carpenter, Guy

AU - Abbate, Vincenzo

AU - Proctor, Gordon

AU - Harvey, Richard D

AU - Gambogi, Robert J

AU - Geonnotti, Anthony

AU - Hider, Robert

AU - Jones, Stuart A

PY - 2018/2/2

Y1 - 2018/2/2

N2 - ‘Soft’ nanomaterials have the potential to produce substantive antibiofilm effects. The aim of this study was to understand the oral antimicrobial activity of soft nanomaterials generated from alpha-tocopherol (α-T) and alpha-tocopherol phosphate (α-TP). (+) α-TP formed planar bilayer islands (175 ± 21 nm, −14.9 ± 3.5 mV) in a Trizma® buffer, whereas (+) α-T formed spherical liposomes (563 ± 1 nm, −10.5 ± 0.2 mV). The (+) α-TP bilayers displayed superior Streptococcus oralis biofilm growth retardation, a more substantive action, generated a superior adsorption to hydroxyapatite and showed an enhanced inhibition of multi-species bacterial saliva biofilm growth (38 ± 7μm vs 58 ± 18 μm, P ˂ 0.05) compared to (+) α-T. Atomic force microscopy data indicated that the ability of the ‘soft’ α-TP nanomaterials to transition into planar bilayer structures upon contact with interfaces facilitated their adhesive properties and substantive antimicrobial effects.

AB - ‘Soft’ nanomaterials have the potential to produce substantive antibiofilm effects. The aim of this study was to understand the oral antimicrobial activity of soft nanomaterials generated from alpha-tocopherol (α-T) and alpha-tocopherol phosphate (α-TP). (+) α-TP formed planar bilayer islands (175 ± 21 nm, −14.9 ± 3.5 mV) in a Trizma® buffer, whereas (+) α-T formed spherical liposomes (563 ± 1 nm, −10.5 ± 0.2 mV). The (+) α-TP bilayers displayed superior Streptococcus oralis biofilm growth retardation, a more substantive action, generated a superior adsorption to hydroxyapatite and showed an enhanced inhibition of multi-species bacterial saliva biofilm growth (38 ± 7μm vs 58 ± 18 μm, P ˂ 0.05) compared to (+) α-T. Atomic force microscopy data indicated that the ability of the ‘soft’ α-TP nanomaterials to transition into planar bilayer structures upon contact with interfaces facilitated their adhesive properties and substantive antimicrobial effects.

U2 - 10.1016/j.nano.2017.12.024

DO - 10.1016/j.nano.2017.12.024

M3 - Article

JO - Nanomedicine: Nanotechnology, Biology and Medicine

JF - Nanomedicine: Nanotechnology, Biology and Medicine

SN - 1549-9634

ER -