Social Anxiety in Cornelia de Lange Syndrome

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Colleges, School and Institutes


In this study we assessed the behavioral presentation of social anxiety in Cornelia de Lange syndrome (CdLS) using a contrast group of Cri du Chat syndrome (CdCS). Behaviors indicative of social anxiety were recorded in twelve children with CdLS (mean age = 11.00; SD = 5.15) and twelve children with CdCS (8.20; SD = 2.86) during social interaction. Lag sequential analysis revealed that participants with CdLS were significantly more likely to evidence behavior indicative of anxiety in close temporal proximity to the point at which they maintained eye contact or spoke. Individuals with CdLS demonstrate a heightened probability of anxiety related behavior during social interaction but only at the point at which social demand is high.


Original languageEnglish
Pages (from-to)1155-1162
JournalJournal of Autism and Developmental Disorders
Issue number8
Early online date28 Mar 2009
Publication statusPublished - Aug 2009


  • Cri du Chat syndrome, Behavioral phenotype, Anxiety, Cornelia de Lange syndrome, Autism spectrum disorder, Social anxiety