Smoke exposure as a determinant of auto-antibody titre in AATD and COPD.

Research output: Contribution to journalArticle



Liberation of elastin peptides from damaged lung may be a mechanism of autoimmune lung disease. Citrullination, and anti-citrullinated protein antibody formation occurs in smokers, but the role of smoking in autoantibody generation relevant to pulmonary disease is unclear. Anti-elastin, anti CCP and anti-MCV antibodies were measured in 257 subjects with alpha 1 antitrypsin deficiency (AATD) , 113 subjects with usual COPD and 22 healthy non-smokers. Levels were compared between groups, against phenotypic features, and against smoke exposure. Anti-elastin antibodies were higher in controls relative to AATD (p=0.008) and usual COPD (p


Original languageEnglish
Pages (from-to)32-38
Number of pages7
JournalThe European respiratory journal
Publication statusPublished - 4 Jun 2010