Small Nucleolar RNAs Tell a Different Tale

Research output: Contribution to journalReview articlepeer-review


Colleges, School and Institutes

External organisations

  • Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, Pawinskiego 5a, 02-106, Warsaw, Poland.
  • School of Biosciences, University of Birmingham


Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase complex employs entirely different strategies, which usually direct the nascent transcript to ribonucleolytic degradation. However, some noncoding RNA classes use endo- and exonucleases to achieve functionality. Here we review processing of small nucleolar RNAs that are transcribed by RNA Polymerase II as precursors, and whose 5' and 3' ends undergo processing to release mature, functional molecules. The maturation strategies of these noncoding RNAs in various organisms follow a similar pattern but employ different factors and are strictly correlated with genomic organisation of their genes.

Bibliographic note

Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.


Original languageEnglish
Pages (from-to)104-117
Number of pages14
JournalTrends in Genetics
Issue number2
Early online date16 Dec 2018
Publication statusPublished - 1 Feb 2019


  • RNA processing, small nucleolar RNA, snoRNA, transcription termination