Projects per year
Abstract
Sleep is pivotal for memory consolidation. According to two-stage accounts, memory traces are gradually translocated from hippocampus to neocortex during non-rapid-eye-movement (NREM) sleep. Mechanistically, this information transfer is thought to rely on interactions between thalamocortical spindles and hippocampal ripples. To test this hypothesis, we analyzed intracranial and scalp Electroencephalography sleep recordings from pre-surgical epilepsy patients. We first observed a concurrent spindle power increase in hippocampus (HIPP) and neocortex (NC) time-locked to individual hippocampal ripple events. Coherence analysis confirmed elevated levels of hippocampal-neocortical spindle coupling around ripples, with directionality analyses indicating an influence from NC to HIPP. Importantly, these hippocampal-neocortical dynamics were particularly pronounced during long-duration compared to short-duration ripples. Together, our findings reveal a potential mechanism underlying active consolidation, comprising a neocortical-hippocampal-neocortical reactivation loop initiated by the neocortex. This hippocampal-cortical dialogue is mediated by sleep spindles and is enhanced during long-duration hippocampal ripples.
Original language | English |
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Article number | e57011 |
Pages (from-to) | 1-18 |
Number of pages | 18 |
Journal | eLife |
Volume | 9 |
DOIs | |
Publication status | Published - 13 Jul 2020 |
Bibliographical note
© 2020, Ngo et al.Keywords
- hippocampus
- human
- neuroscience
- ripples
- sleep
- spindles
ASJC Scopus subject areas
- Neuroscience(all)
- Immunology and Microbiology(all)
- Biochemistry, Genetics and Molecular Biology(all)
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- 1 Finished
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Episodic memory during offline periods
Staresina, B. & Shapiro, K.
The Royal Society, THE WELLCOME TRUST
1/02/16 → 1/08/21
Project: Research
Equipment
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Birmingham Environment for Academic Research (BEAR)
Facility/equipment: Equipment