Sleep in children with Smith-Magenis syndrome: a case-control actigraphy study
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Sleep in children with Smith-Magenis syndrome : a case-control actigraphy study. / Trickett, Jayne; Oliver, Chris; Heald, Mary; Denyer, Hayley; Surtees, Andrew; Clarkson, Emma; Gringras, Paul; Richards, Caroline.
In: Sleep, Vol. 43, No. 4, zsz260, 15.04.2020.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Sleep in children with Smith-Magenis syndrome
T2 - a case-control actigraphy study
AU - Trickett, Jayne
AU - Oliver, Chris
AU - Heald, Mary
AU - Denyer, Hayley
AU - Surtees, Andrew
AU - Clarkson, Emma
AU - Gringras, Paul
AU - Richards, Caroline
PY - 2020/4/15
Y1 - 2020/4/15
N2 - Study Objectives: 1) To compare both actigraphy and questionnaire assessed sleep quality and timing in children with Smith-Magenis syndrome (SMS) to a chronologically age-matched typically developing (TD) group. 2) To explore associations between age, nocturnal and diurnal sleep quality and daytime behaviour.Methods: Seven nights of actigraphy data were collected from 20 children with SMS (mean age 8.70; SD 2.70) and 20 TD children. Daily parent/teacher ratings of behaviour and sleepiness were obtained. Mixed linear modelling was used to explore associations between total sleep time and daytime naps and behaviour.Results: Sleep in children with SMS was characterised by shorter total sleep time (TST), extended night waking, shorter sleep onset, more daytime naps and earlier morning waking compared to the TD group. Considerable inter-daily and inter-individual variability in sleep quality was found in the SMS group, so caution in generalising results is required. An expected inverse association between age and TST was found in the TD group, but no significant association was found for the SMS group. No between group differences in sleep hygiene practices were identified. A bidirectional negative association between TST and nap duration was found for the SMS group. In the SMS group increased afternoon sleepiness was associated with increased irritability (p=.007) and overactivity (p=.005).Conclusion: These findings evidence poor sleep quality in SMS and the need to implement evidence-based interventions in this population.
AB - Study Objectives: 1) To compare both actigraphy and questionnaire assessed sleep quality and timing in children with Smith-Magenis syndrome (SMS) to a chronologically age-matched typically developing (TD) group. 2) To explore associations between age, nocturnal and diurnal sleep quality and daytime behaviour.Methods: Seven nights of actigraphy data were collected from 20 children with SMS (mean age 8.70; SD 2.70) and 20 TD children. Daily parent/teacher ratings of behaviour and sleepiness were obtained. Mixed linear modelling was used to explore associations between total sleep time and daytime naps and behaviour.Results: Sleep in children with SMS was characterised by shorter total sleep time (TST), extended night waking, shorter sleep onset, more daytime naps and earlier morning waking compared to the TD group. Considerable inter-daily and inter-individual variability in sleep quality was found in the SMS group, so caution in generalising results is required. An expected inverse association between age and TST was found in the TD group, but no significant association was found for the SMS group. No between group differences in sleep hygiene practices were identified. A bidirectional negative association between TST and nap duration was found for the SMS group. In the SMS group increased afternoon sleepiness was associated with increased irritability (p=.007) and overactivity (p=.005).Conclusion: These findings evidence poor sleep quality in SMS and the need to implement evidence-based interventions in this population.
KW - actigraphy
KW - behavior
KW - intellectual disability
KW - sleep
KW - Smith–Magenis syndrome
UR - http://www.scopus.com/inward/record.url?scp=85076245020&partnerID=8YFLogxK
U2 - 10.1093/sleep/zsz260
DO - 10.1093/sleep/zsz260
M3 - Article
C2 - 31630201
AN - SCOPUS:85076245020
VL - 43
JO - Sleep
JF - Sleep
SN - 0161-8105
IS - 4
M1 - zsz260
ER -