Sleep duration and memory in the elderly Chinese: longitudinal analysis of the Guangzhou Biobank Cohort Study

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Sleep duration and memory in the elderly Chinese : longitudinal analysis of the Guangzhou Biobank Cohort Study. / Xu, Lin; Jiang, Chao Qiang; Lam, Tai Hing; Zhang, Wei Sen; Cherny, Stacey Shawn; Thomas, G Neil; Cheng, Kar Keung.

In: Sleep, Vol. 37, No. 11, 11.2014, p. 1737-44.

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Xu, Lin ; Jiang, Chao Qiang ; Lam, Tai Hing ; Zhang, Wei Sen ; Cherny, Stacey Shawn ; Thomas, G Neil ; Cheng, Kar Keung. / Sleep duration and memory in the elderly Chinese : longitudinal analysis of the Guangzhou Biobank Cohort Study. In: Sleep. 2014 ; Vol. 37, No. 11. pp. 1737-44.

Bibtex

@article{3b92971e609341f39b68b35789ddd327,
title = "Sleep duration and memory in the elderly Chinese: longitudinal analysis of the Guangzhou Biobank Cohort Study",
abstract = "STUDY OBJECTIVES: Previous cross-sectional studies showed that short or long sleep duration was associated with memory impairment (MI), but longitudinal studies are scarce. We examined whether sleep duration was associated with memory decline or development of MI.DESIGN SETTING PARTICIPANTS: We conducted a prospective analysis based on the Guangzhou Biobank Cohort Study on 13,888 participants aged 50+ years without MI at baseline and with a follow-up for a mean of 4.1 years.MEASURES AND RESULTS: Memory decline was assessed using the Delayed 10-Word Recall Test (DWRT), and in a subset (n = 6,020) with the Mini-Mental State Examination (MMSE). Short and long sleep duration was defined as ≤ 5 hours/day and ≥ 9 hours/day, respectively. Data were analyzed both continuously for memory decline and dichotomously for MI (independently defined as DWRT, < 4; MMSE, < 25). After adjusting for multiple potential confounders, both short and long sleep durations were associated with memory decline using DWRT or MMSE score changes (all P < 0.001). Seven percent (n = 980) developed DWRT-defined MI and 4.0% (n = 194) MMSE-defined MI during the follow-up. Only those with a short (≤ 5 h/day) sleep duration had a significantly increased risk of DWRT-defined MI (odds ratio = 1.53 (95% confidence interval; 1.21-1.93); P < 0.001) relative to normal sleepers (7 h/day). The association remained significant after excluding those with poor self-reported health. No associations were observed with MMSE-defined MI for both long and short sleep durations.CONCLUSIONS: This is the largest study to date addressing the association between extremes of sleep duration and memory decline. The observed adverse relationships provide support for an intervention study to examine the potential benefits of normalizing sleep duration in attenuating memory decline.",
keywords = "Aged, Aged, 80 and over, Asian Continental Ancestry Group, Biological Specimen Banks, Female, Humans, Language, Longitudinal Studies, Male, Memory Disorders, Mental Recall, Middle Aged, Neuropsychological Tests, Odds Ratio, Prospective Studies, Sleep, Time Factors",
author = "Lin Xu and Jiang, {Chao Qiang} and Lam, {Tai Hing} and Zhang, {Wei Sen} and Cherny, {Stacey Shawn} and Thomas, {G Neil} and Cheng, {Kar Keung}",
year = "2014",
month = nov,
doi = "10.5665/sleep.4162",
language = "English",
volume = "37",
pages = "1737--44",
journal = "Sleep",
issn = "0161-8105",
publisher = "American Academy of Sleep Medicine",
number = "11",

}

RIS

TY - JOUR

T1 - Sleep duration and memory in the elderly Chinese

T2 - longitudinal analysis of the Guangzhou Biobank Cohort Study

AU - Xu, Lin

AU - Jiang, Chao Qiang

AU - Lam, Tai Hing

AU - Zhang, Wei Sen

AU - Cherny, Stacey Shawn

AU - Thomas, G Neil

AU - Cheng, Kar Keung

PY - 2014/11

Y1 - 2014/11

N2 - STUDY OBJECTIVES: Previous cross-sectional studies showed that short or long sleep duration was associated with memory impairment (MI), but longitudinal studies are scarce. We examined whether sleep duration was associated with memory decline or development of MI.DESIGN SETTING PARTICIPANTS: We conducted a prospective analysis based on the Guangzhou Biobank Cohort Study on 13,888 participants aged 50+ years without MI at baseline and with a follow-up for a mean of 4.1 years.MEASURES AND RESULTS: Memory decline was assessed using the Delayed 10-Word Recall Test (DWRT), and in a subset (n = 6,020) with the Mini-Mental State Examination (MMSE). Short and long sleep duration was defined as ≤ 5 hours/day and ≥ 9 hours/day, respectively. Data were analyzed both continuously for memory decline and dichotomously for MI (independently defined as DWRT, < 4; MMSE, < 25). After adjusting for multiple potential confounders, both short and long sleep durations were associated with memory decline using DWRT or MMSE score changes (all P < 0.001). Seven percent (n = 980) developed DWRT-defined MI and 4.0% (n = 194) MMSE-defined MI during the follow-up. Only those with a short (≤ 5 h/day) sleep duration had a significantly increased risk of DWRT-defined MI (odds ratio = 1.53 (95% confidence interval; 1.21-1.93); P < 0.001) relative to normal sleepers (7 h/day). The association remained significant after excluding those with poor self-reported health. No associations were observed with MMSE-defined MI for both long and short sleep durations.CONCLUSIONS: This is the largest study to date addressing the association between extremes of sleep duration and memory decline. The observed adverse relationships provide support for an intervention study to examine the potential benefits of normalizing sleep duration in attenuating memory decline.

AB - STUDY OBJECTIVES: Previous cross-sectional studies showed that short or long sleep duration was associated with memory impairment (MI), but longitudinal studies are scarce. We examined whether sleep duration was associated with memory decline or development of MI.DESIGN SETTING PARTICIPANTS: We conducted a prospective analysis based on the Guangzhou Biobank Cohort Study on 13,888 participants aged 50+ years without MI at baseline and with a follow-up for a mean of 4.1 years.MEASURES AND RESULTS: Memory decline was assessed using the Delayed 10-Word Recall Test (DWRT), and in a subset (n = 6,020) with the Mini-Mental State Examination (MMSE). Short and long sleep duration was defined as ≤ 5 hours/day and ≥ 9 hours/day, respectively. Data were analyzed both continuously for memory decline and dichotomously for MI (independently defined as DWRT, < 4; MMSE, < 25). After adjusting for multiple potential confounders, both short and long sleep durations were associated with memory decline using DWRT or MMSE score changes (all P < 0.001). Seven percent (n = 980) developed DWRT-defined MI and 4.0% (n = 194) MMSE-defined MI during the follow-up. Only those with a short (≤ 5 h/day) sleep duration had a significantly increased risk of DWRT-defined MI (odds ratio = 1.53 (95% confidence interval; 1.21-1.93); P < 0.001) relative to normal sleepers (7 h/day). The association remained significant after excluding those with poor self-reported health. No associations were observed with MMSE-defined MI for both long and short sleep durations.CONCLUSIONS: This is the largest study to date addressing the association between extremes of sleep duration and memory decline. The observed adverse relationships provide support for an intervention study to examine the potential benefits of normalizing sleep duration in attenuating memory decline.

KW - Aged

KW - Aged, 80 and over

KW - Asian Continental Ancestry Group

KW - Biological Specimen Banks

KW - Female

KW - Humans

KW - Language

KW - Longitudinal Studies

KW - Male

KW - Memory Disorders

KW - Mental Recall

KW - Middle Aged

KW - Neuropsychological Tests

KW - Odds Ratio

KW - Prospective Studies

KW - Sleep

KW - Time Factors

U2 - 10.5665/sleep.4162

DO - 10.5665/sleep.4162

M3 - Article

C2 - 25364069

VL - 37

SP - 1737

EP - 1744

JO - Sleep

JF - Sleep

SN - 0161-8105

IS - 11

ER -