Size matters: Increased grey matter in boys with conduct problems and callousunemotional traits

Research output: Contribution to journalArticlepeer-review

Standard

Size matters : Increased grey matter in boys with conduct problems and callousunemotional traits. / De Brito, Stephane; Laurens, K.R.; Hodgins, S.; Mechelli, A.; Wilke, M.; Jones, A.P.; Viding, E.; Barker, G.J.

In: Brain, Vol. 132, No. 4, 01.04.2009, p. 843-852.

Research output: Contribution to journalArticlepeer-review

Harvard

De Brito, S, Laurens, KR, Hodgins, S, Mechelli, A, Wilke, M, Jones, AP, Viding, E & Barker, GJ 2009, 'Size matters: Increased grey matter in boys with conduct problems and callousunemotional traits', Brain, vol. 132, no. 4, pp. 843-852. https://doi.org/10.1093/brain/awp011

APA

De Brito, S., Laurens, K. R., Hodgins, S., Mechelli, A., Wilke, M., Jones, A. P., Viding, E., & Barker, G. J. (2009). Size matters: Increased grey matter in boys with conduct problems and callousunemotional traits. Brain, 132(4), 843-852. https://doi.org/10.1093/brain/awp011

Vancouver

Author

De Brito, Stephane ; Laurens, K.R. ; Hodgins, S. ; Mechelli, A. ; Wilke, M. ; Jones, A.P. ; Viding, E. ; Barker, G.J. / Size matters : Increased grey matter in boys with conduct problems and callousunemotional traits. In: Brain. 2009 ; Vol. 132, No. 4. pp. 843-852.

Bibtex

@article{ba8a94222aeb49ed80b521b3e01b7b05,
title = "Size matters: Increased grey matter in boys with conduct problems and callousunemotional traits",
abstract = "Brain imaging studies of adults with psychopathy have identified structural and functional abnormalities in limbic and prefrontal regions that are involved in emotion recognition, decision-making, morality and empathy. Among children with conduct problems, a small subgroup presents callousunemotional traits thought to be antecedents of psychopathy. No structural brain imaging study has examined this subgroup of children. The present study used voxel-based morphometry to compare whole brain grey matter volumes and concentrations of boys with elevated levels of callousunemotional conduct problems and typically developing boys and explored four a priori regions of interest. sMRI scans were collected from 23 boys with elevated levels of callousunemotional conduct problems (mean age 11 years 8 months) and 25 typically developing boys (mean age 11 years 6 months) selected from a community sample of children. Data were analysed using optimized voxel-based morphometry. Study-specific probability maps were created and four a priori regions of interest identified (orbitofrontal, anterior cingulate and anterior insular cortices and amygdala). Both grey matter volume and concentration were examined controlling for cognitive ability and hyperactivityinattention symptoms. Boys with callousunemotional conduct problems, as compared with typically developing boys, presented increased grey matter concentration in the medial orbitofrontal and anterior cingulate cortices, as well as increased grey matter volume and concentration in the temporal lobes bilaterally. These findings may indicate a delay in cortical maturation in several brain areas implicated in decision making, morality and empathy in boys with callousunemotional conduct problems.",
author = "{De Brito}, Stephane and K.R. Laurens and S. Hodgins and A. Mechelli and M. Wilke and A.P. Jones and E. Viding and G.J. Barker",
year = "2009",
month = apr,
day = "1",
doi = "10.1093/brain/awp011",
language = "English",
volume = "132",
pages = "843--852",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Size matters

T2 - Increased grey matter in boys with conduct problems and callousunemotional traits

AU - De Brito, Stephane

AU - Laurens, K.R.

AU - Hodgins, S.

AU - Mechelli, A.

AU - Wilke, M.

AU - Jones, A.P.

AU - Viding, E.

AU - Barker, G.J.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - Brain imaging studies of adults with psychopathy have identified structural and functional abnormalities in limbic and prefrontal regions that are involved in emotion recognition, decision-making, morality and empathy. Among children with conduct problems, a small subgroup presents callousunemotional traits thought to be antecedents of psychopathy. No structural brain imaging study has examined this subgroup of children. The present study used voxel-based morphometry to compare whole brain grey matter volumes and concentrations of boys with elevated levels of callousunemotional conduct problems and typically developing boys and explored four a priori regions of interest. sMRI scans were collected from 23 boys with elevated levels of callousunemotional conduct problems (mean age 11 years 8 months) and 25 typically developing boys (mean age 11 years 6 months) selected from a community sample of children. Data were analysed using optimized voxel-based morphometry. Study-specific probability maps were created and four a priori regions of interest identified (orbitofrontal, anterior cingulate and anterior insular cortices and amygdala). Both grey matter volume and concentration were examined controlling for cognitive ability and hyperactivityinattention symptoms. Boys with callousunemotional conduct problems, as compared with typically developing boys, presented increased grey matter concentration in the medial orbitofrontal and anterior cingulate cortices, as well as increased grey matter volume and concentration in the temporal lobes bilaterally. These findings may indicate a delay in cortical maturation in several brain areas implicated in decision making, morality and empathy in boys with callousunemotional conduct problems.

AB - Brain imaging studies of adults with psychopathy have identified structural and functional abnormalities in limbic and prefrontal regions that are involved in emotion recognition, decision-making, morality and empathy. Among children with conduct problems, a small subgroup presents callousunemotional traits thought to be antecedents of psychopathy. No structural brain imaging study has examined this subgroup of children. The present study used voxel-based morphometry to compare whole brain grey matter volumes and concentrations of boys with elevated levels of callousunemotional conduct problems and typically developing boys and explored four a priori regions of interest. sMRI scans were collected from 23 boys with elevated levels of callousunemotional conduct problems (mean age 11 years 8 months) and 25 typically developing boys (mean age 11 years 6 months) selected from a community sample of children. Data were analysed using optimized voxel-based morphometry. Study-specific probability maps were created and four a priori regions of interest identified (orbitofrontal, anterior cingulate and anterior insular cortices and amygdala). Both grey matter volume and concentration were examined controlling for cognitive ability and hyperactivityinattention symptoms. Boys with callousunemotional conduct problems, as compared with typically developing boys, presented increased grey matter concentration in the medial orbitofrontal and anterior cingulate cortices, as well as increased grey matter volume and concentration in the temporal lobes bilaterally. These findings may indicate a delay in cortical maturation in several brain areas implicated in decision making, morality and empathy in boys with callousunemotional conduct problems.

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U2 - 10.1093/brain/awp011

DO - 10.1093/brain/awp011

M3 - Article

AN - SCOPUS:65249122503

VL - 132

SP - 843

EP - 852

JO - Brain

JF - Brain

SN - 0006-8950

IS - 4

ER -