Size matters: Increased grey matter in boys with conduct problems and callousunemotional traits

Research output: Contribution to journalArticlepeer-review

Authors

  • K.R. Laurens
  • S. Hodgins
  • A. Mechelli
  • M. Wilke
  • A.P. Jones
  • E. Viding
  • G.J. Barker

Colleges, School and Institutes

External organisations

  • King’s College London
  • University College London Hospitals NHS Foundation Trust
  • University College London
  • University of Tbingen

Abstract

Brain imaging studies of adults with psychopathy have identified structural and functional abnormalities in limbic and prefrontal regions that are involved in emotion recognition, decision-making, morality and empathy. Among children with conduct problems, a small subgroup presents callousunemotional traits thought to be antecedents of psychopathy. No structural brain imaging study has examined this subgroup of children. The present study used voxel-based morphometry to compare whole brain grey matter volumes and concentrations of boys with elevated levels of callousunemotional conduct problems and typically developing boys and explored four a priori regions of interest. sMRI scans were collected from 23 boys with elevated levels of callousunemotional conduct problems (mean age 11 years 8 months) and 25 typically developing boys (mean age 11 years 6 months) selected from a community sample of children. Data were analysed using optimized voxel-based morphometry. Study-specific probability maps were created and four a priori regions of interest identified (orbitofrontal, anterior cingulate and anterior insular cortices and amygdala). Both grey matter volume and concentration were examined controlling for cognitive ability and hyperactivityinattention symptoms. Boys with callousunemotional conduct problems, as compared with typically developing boys, presented increased grey matter concentration in the medial orbitofrontal and anterior cingulate cortices, as well as increased grey matter volume and concentration in the temporal lobes bilaterally. These findings may indicate a delay in cortical maturation in several brain areas implicated in decision making, morality and empathy in boys with callousunemotional conduct problems.

Details

Original languageEnglish
Pages (from-to)843-852
Number of pages10
JournalBrain
Volume132
Issue number4
Early online date17 Mar 2009
Publication statusPublished - 1 Apr 2009