Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis

Sally Fenton; Aamer Sandoo; George Metsios; Joan Duda; George Kitas; Jet Veldhuijzen van Zanten

doi:10.1016/j.mvr.2018.01.005

Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis

Sally Fenton, Aamer Sandoo, George Metsios, Joan Duda, George Kitas, Jet Veldhuijzen van Zanten

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Abstract

BACKGROUND: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood.

OBJECTIVES: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA.

METHODS: Sixty-eight RA patients (Mage = 55 ± 12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire).

RESULTS: Regressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = -3.25, p = .02, 95% CI [-6.07, -.42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN).

CONCLUSION: Habitual sitting time appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.

Original language	English
Pages (from-to)	57-60
Journal	Microvascular Research
Volume	117
Early online date	21 Feb 2018
DOIs	https://doi.org/10.1016/j.mvr.2018.01.005
Publication status	Published - May 2018

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Fenton_et_al_Sitting_time_Microvascular_ResearchAccepted author manuscript, 154 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

Cite this

@article{bc6365a272a54b4cb3999f6fe958e3bc,

title = "Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis",

abstract = "BACKGROUND: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood.OBJECTIVES: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA.METHODS: Sixty-eight RA patients (Mage = 55 ± 12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire).RESULTS: Regressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = -3.25, p = .02, 95% CI [-6.07, -.42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN).CONCLUSION: Habitual sitting time appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.",

keywords = "Journal Article",

author = "Sally Fenton and Aamer Sandoo and George Metsios and Joan Duda and George Kitas and {van Zanten}, {Jet Veldhuijzen}",

note = "Copyright {\textcopyright} 2017. Published by Elsevier Inc.",

year = "2018",

month = may,

doi = "10.1016/j.mvr.2018.01.005",

language = "English",

volume = "117",

pages = "57--60",

journal = "Microvascular Research",

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TY - JOUR

T1 - Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis

AU - Fenton, Sally

AU - Sandoo, Aamer

AU - Metsios, George

AU - Duda, Joan

AU - Kitas, George

AU - van Zanten, Jet Veldhuijzen

PY - 2018/5

Y1 - 2018/5

N2 - BACKGROUND: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood.OBJECTIVES: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA.METHODS: Sixty-eight RA patients (Mage = 55 ± 12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire).RESULTS: Regressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = -3.25, p = .02, 95% CI [-6.07, -.42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN).CONCLUSION: Habitual sitting time appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.

AB - BACKGROUND: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood.OBJECTIVES: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA.METHODS: Sixty-eight RA patients (Mage = 55 ± 12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire).RESULTS: Regressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = -3.25, p = .02, 95% CI [-6.07, -.42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN).CONCLUSION: Habitual sitting time appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.

KW - Journal Article

U2 - 10.1016/j.mvr.2018.01.005

DO - 10.1016/j.mvr.2018.01.005

M3 - Article

C2 - 29355580

SN - 0026-2862

VL - 117

SP - 57

EP - 60

JO - Microvascular Research

JF - Microvascular Research

ER -

Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis

Abstract

Keywords

UN SDGs

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