Sitting time is negatively related to microvascular endothelium-dependent function in rheumatoid arthritis

Research output: Contribution to journalArticle

Authors

  • Aamer Sandoo
  • George Metsios
  • George Kitas
  • Jet Veldhuijzen van Zanten

Colleges, School and Institutes

External organisations

  • School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom; Department of Rheumatology, Russells Hall Hospital, Dudley Group NHS Foundation Trust, Dudley, United Kingdom. Electronic address: s.a.m.fenton@bham.ac.uk.
  • Bangor University
  • Department of Rheumatology, Russells Hall Hospital, Dudley Group NHS Foundation Trust, Dudley, United Kingdom; Faculty of Health Education and Wellbeing, University of Wolverhampton, West Midlands, United Kingdom.
  • School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. Electronic address: Axh547@bham.ac.uk.
  • School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, B15 2TT, United Kingdom; Department of Rheumatology, Russells Hall Hospital, Dudley Group NHS Foundation Trust, Dudley, United Kingdom.

Abstract

BACKGROUND: Sedentary behaviour is linked to increased cardiovascular disease risk in Rheumatoid Arthritis (RA), but the biological processes underlying this relationship are not understood.

OBJECTIVES: To investigate the cross-sectional associations of habitual sedentary behaviour, with endothelial function in RA.

METHODS: Sixty-eight RA patients (Mage = 55 ± 12 years) underwent Laser Doppler Imaging with iontophoresis, to assess microvascular endothelium-dependent (acetylcholine, ACh) and endothelium-independent (sodium nitroprusside, SNP) function. Large-vessel endothelium-dependent and endothelium-independent functions were measured via flow-mediated dilation (FMD) and glyceryl trinitrate dilation (GTN), respectively. Habitual sedentary behaviour (hours/week sitting) was self-reported (International Physical Activity Questionnaire).

RESULTS: Regressions revealed sitting time significantly negatively predicted microvascular endothelium-dependent function (ACh, unstandardizedβ = -3.25, p = .02, 95% CI [-6.07, -.42], R2 = 0.06), but did not associate with other endothelial function outcomes (SNP, FMD, GTN).

CONCLUSION: Habitual sitting time appears to be adversely linked to microvascular endothelium-dependent function among people living with RA.

Details

Original languageEnglish
Pages (from-to)57-60
JournalMicrovascular Research
Volume117
Early online date21 Feb 2018
Publication statusPublished - May 2018

Keywords

  • Journal Article