Single molecule methods for the study of catalysis: from enzymes to heterogeneous catalysts

Research output: Contribution to journalArticlepeer-review

Authors

  • K Janssen
  • Gert De Cremer
  • Alexey Kubarev
  • Jordi Van Loon
  • Johan A. Martens
  • Dirk E. De Vos
  • Maarten B. J. Roeffaers
  • John Hofkens

Colleges, School and Institutes

Abstract

Structural and temporal inhomogeneities can have a marked influence on the performance of inorganic and biocatalytic systems alike. While these subtle variations are hardly ever accessible through bulk or ensemble averaged activity screening, insights into the molecular mechanisms underlying these diverse phenomena are absolutely critical for the development of optimized or novel catalytic systems and processes. Fortunately, state-of-the-art fluorescence microscopy methods have allowed experimental access to this intriguing world at the nanoscale. In this tutorial review we will first provide a broad overview of key concepts and developments in the application of single molecule fluorescence spectroscopy to (bio)catalysis research. In the second part topics specific to both bio and heterogeneous catalysis will be reviewed in more detail.

Details

Original languageEnglish
Pages (from-to)990-1006
JournalChemical Society Reviews
Volume43
Issue number4
Early online date1 Oct 2013
Publication statusPublished - 2014