Abstract
A three-component chiral derivatization protocol for determining the enantiopurity of chiral diols by H-1 NMR spectroscopic analysis is described here. The present approach involves the derivatization of 1,2-1,3- and 1,4-diols with 2-formylphenylboronic acid and enantiopure alpha-methylbenzylamine. This method affords a mixture of diastereoisomeric iminoboronate esters whose ratio can be determined by integration of well-resolved diastereotopic resonances in their H-1 NMR spectra, thus enabling the determination of the enantiopurity of the parent diol. The protocol as described takes less than 90 min to complete.
| Original language | English |
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| Pages (from-to) | 215-219 |
| Number of pages | 5 |
| Journal | Nature protocols |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1 Jan 2008 |