Similar effects of intranasal oxytocin administration and acute alcohol consumption on socio-cognitions, emotions and behaviour: implications for the mechanisms of action

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@article{005d1bcfba0f4fd9ac2eac87f13a55bc,
title = "Similar effects of intranasal oxytocin administration and acute alcohol consumption on socio-cognitions, emotions and behaviour: implications for the mechanisms of action",
abstract = "Oxytocin (OT) plays a critical role in the formation of long lasting social attachments across a range of mammalian species. Raising intracerebral OT levels by intranasal administration of the neuropeptide (inOT) can also have pronounced effects on human sociocognitive functioning. inOT has been associated with increasing altruism, generosity, empathy and trust while decreasing fear, anxiety and stress reactions via neural mechanisms which are yet to be fully elucidated. The observation of the prosocial effects of OT has led to speculation about the role the peptide might play in some psychiatric conditions and debate as to its potential therapeutic uses. Here we note the great similarity in the sociocognitive effects that can be induced by inOT and the effects of acute consumption of modest does of alcohol. We further reflect on how both compounds may act on limbic and prefrontal cortical structures to increase GABAergic transmission, thereby facilitating the release of prepotent responses, that is, more automatic responses which are associated with earlier developmental stages.",
keywords = "Oxytocin, alcohol, GABA, prepotent, prosocial behavior, development",
author = "Ian Mitchell and Gillespie, {Steven Mark} and Ahmad Abu-Akel",
year = "2015",
month = "8",
doi = "10.1016/j.neubiorev.2015.04.018",
language = "English",
volume = "55",
pages = "98--106",
journal = "Neuroscience and biobehavioral reviews",
issn = "0149-7634",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Similar effects of intranasal oxytocin administration and acute alcohol consumption on socio-cognitions, emotions and behaviour

T2 - implications for the mechanisms of action

AU - Mitchell, Ian

AU - Gillespie, Steven Mark

AU - Abu-Akel, Ahmad

PY - 2015/8

Y1 - 2015/8

N2 - Oxytocin (OT) plays a critical role in the formation of long lasting social attachments across a range of mammalian species. Raising intracerebral OT levels by intranasal administration of the neuropeptide (inOT) can also have pronounced effects on human sociocognitive functioning. inOT has been associated with increasing altruism, generosity, empathy and trust while decreasing fear, anxiety and stress reactions via neural mechanisms which are yet to be fully elucidated. The observation of the prosocial effects of OT has led to speculation about the role the peptide might play in some psychiatric conditions and debate as to its potential therapeutic uses. Here we note the great similarity in the sociocognitive effects that can be induced by inOT and the effects of acute consumption of modest does of alcohol. We further reflect on how both compounds may act on limbic and prefrontal cortical structures to increase GABAergic transmission, thereby facilitating the release of prepotent responses, that is, more automatic responses which are associated with earlier developmental stages.

AB - Oxytocin (OT) plays a critical role in the formation of long lasting social attachments across a range of mammalian species. Raising intracerebral OT levels by intranasal administration of the neuropeptide (inOT) can also have pronounced effects on human sociocognitive functioning. inOT has been associated with increasing altruism, generosity, empathy and trust while decreasing fear, anxiety and stress reactions via neural mechanisms which are yet to be fully elucidated. The observation of the prosocial effects of OT has led to speculation about the role the peptide might play in some psychiatric conditions and debate as to its potential therapeutic uses. Here we note the great similarity in the sociocognitive effects that can be induced by inOT and the effects of acute consumption of modest does of alcohol. We further reflect on how both compounds may act on limbic and prefrontal cortical structures to increase GABAergic transmission, thereby facilitating the release of prepotent responses, that is, more automatic responses which are associated with earlier developmental stages.

KW - Oxytocin

KW - alcohol

KW - GABA

KW - prepotent

KW - prosocial behavior

KW - development

U2 - 10.1016/j.neubiorev.2015.04.018

DO - 10.1016/j.neubiorev.2015.04.018

M3 - Article

VL - 55

SP - 98

EP - 106

JO - Neuroscience and biobehavioral reviews

JF - Neuroscience and biobehavioral reviews

SN - 0149-7634

ER -