Short-Term Hemodynamic Effects of Cardiac Resynchronization Therapy in Patients With Heart Failure, a Narrow QRS Duration, and No Dyssynchrony

Research output: Contribution to journalArticle


  • S Ellery
  • Kiran Patel
  • F Leyva
  • RA Bleasdale
  • B Stegemann
  • V Paul
  • P Steendijk

Colleges, School and Institutes


Background-Cardiac resynchronization therapy produces both short-term hemodynamic and long-term symptomatic/mortality benefits in symptomatic heart failure patients with a QRS duration > 120 ms. This is conventionally believed to be due principally to relief of dyssynchrony, although we recently showed that relief of external constraint to left ventricular filling may also play a role. In this study, we evaluated the short-term hemodynamic effects in symptomatic patients with a QRS duration <120 ms and no evidence of dyssynchrony on conventional criteria and assessed the effects on contractility and external constraint. Methods and Results-Thirty heart failure patients (New York Heart Association class III/IV) with a left ventricular ejection fraction


Original languageEnglish
Pages (from-to)1687-1694
Number of pages8
Issue number17
Publication statusPublished - 1 Oct 2009


  • heart failure, hemodynamics, pacing, cardiac output