Sharp Wave-Ripples in Human Amygdala and Their Coordination with Hippocampus during NREM Sleep

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Sharp Wave-Ripples in Human Amygdala and Their Coordination with Hippocampus during NREM Sleep. / Cox, Roy; Rüber, Theodor; Staresina, Bernhard P; Fell, Juergen.

In: Cerebral Cortex Communications, Vol. 1, No. 1, tgaa051, 08.2020.

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@article{a33e3dc93a7a4665ae18cc661de4d6ea,
title = "Sharp Wave-Ripples in Human Amygdala and Their Coordination with Hippocampus during NREM Sleep",
abstract = "Cooperative interactions between the amygdala and hippocampus are widely regarded as critical for overnight emotional processing of waking experiences, but direct support from the human brain for such a dialog is absent. Using overnight intracranial recordings in 4 presurgical epilepsy patients (3 female), we discovered ripples within human amygdala during nonrapid eye movement (NREM) sleep, a brain state known to contribute to affective processing. Like hippocampal ripples, amygdala ripples are associated with sharp waves, linked to sleep spindles, and tend to co-occur with their hippocampal counterparts. Moreover, sharp waves and ripples are temporally linked across the 2 brain structures, with amygdala ripples occurring during hippocampal sharp waves and vice versa. Combined with further evidence of interregional sharp-wave and spindle synchronization, these findings offer a potential physiological substrate for the NREM-sleep-dependent consolidation and regulation of emotional experiences.",
author = "Roy Cox and Theodor R{\"u}ber and Staresina, {Bernhard P} and Juergen Fell",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press.",
year = "2020",
month = aug,
doi = "10.1093/texcom/tgaa051",
language = "English",
volume = "1",
journal = "Cerebral Cortex Communications",
issn = "2632-7376",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Sharp Wave-Ripples in Human Amygdala and Their Coordination with Hippocampus during NREM Sleep

AU - Cox, Roy

AU - Rüber, Theodor

AU - Staresina, Bernhard P

AU - Fell, Juergen

N1 - © The Author(s) 2020. Published by Oxford University Press.

PY - 2020/8

Y1 - 2020/8

N2 - Cooperative interactions between the amygdala and hippocampus are widely regarded as critical for overnight emotional processing of waking experiences, but direct support from the human brain for such a dialog is absent. Using overnight intracranial recordings in 4 presurgical epilepsy patients (3 female), we discovered ripples within human amygdala during nonrapid eye movement (NREM) sleep, a brain state known to contribute to affective processing. Like hippocampal ripples, amygdala ripples are associated with sharp waves, linked to sleep spindles, and tend to co-occur with their hippocampal counterparts. Moreover, sharp waves and ripples are temporally linked across the 2 brain structures, with amygdala ripples occurring during hippocampal sharp waves and vice versa. Combined with further evidence of interregional sharp-wave and spindle synchronization, these findings offer a potential physiological substrate for the NREM-sleep-dependent consolidation and regulation of emotional experiences.

AB - Cooperative interactions between the amygdala and hippocampus are widely regarded as critical for overnight emotional processing of waking experiences, but direct support from the human brain for such a dialog is absent. Using overnight intracranial recordings in 4 presurgical epilepsy patients (3 female), we discovered ripples within human amygdala during nonrapid eye movement (NREM) sleep, a brain state known to contribute to affective processing. Like hippocampal ripples, amygdala ripples are associated with sharp waves, linked to sleep spindles, and tend to co-occur with their hippocampal counterparts. Moreover, sharp waves and ripples are temporally linked across the 2 brain structures, with amygdala ripples occurring during hippocampal sharp waves and vice versa. Combined with further evidence of interregional sharp-wave and spindle synchronization, these findings offer a potential physiological substrate for the NREM-sleep-dependent consolidation and regulation of emotional experiences.

U2 - 10.1093/texcom/tgaa051

DO - 10.1093/texcom/tgaa051

M3 - Article

C2 - 33015623

VL - 1

JO - Cerebral Cortex Communications

JF - Cerebral Cortex Communications

SN - 2632-7376

IS - 1

M1 - tgaa051

ER -