SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus

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Abstract

Objective To examine change in health-related quality of life in association with clinical outcomes of neuropsychiatric events in systemic lupus erythematosus (SLE). Methods An international study evaluated newly diagnosed SLE patients for neuropsychiatric events attributed to SLE and non-SLE causes. The outcome of events was determined by a physician-completed seven-point scale and compared with patient-completed Short Form 36 (SF-36) health survey questionnaires. Statistical analysis used linear mixed-effects regression models with patient-specific random effects. Results 274 patients (92% female; 68% Caucasian), from a cohort of 1400, had one or more neuropsychiatric event in which the interval between assessments was 12.3+/-2 months. The overall difference in change between visits in mental component summary (MCS) scores of the SF-36 was significant (p

Details

Original languageEnglish
Pages (from-to)961-967
Number of pages7
JournalAnnals of the Rheumatic Diseases
Volume70
Issue number6
Publication statusPublished - 1 Jun 2011