TY - JOUR
T1 - Sex differences in the interleukin-6 response to acute psychological stress
AU - Edwards, Kathryn
AU - Burns, Victoria
AU - Ring, Christopher
AU - Carroll, Douglas
PY - 2006/3/1
Y1 - 2006/3/1
N2 - Interleukin-6 (IL-6), an immune regulator that helps coordinate the inflammatory response, may mediate inflammatory disease exacerbation associated with stress. Twenty men and twenty women completed a single session, comprising baseline (20 min), mental arithmetic task (8 min), and recovery (60 min). Blood samples, taken at baseline, immediately after the task, and at +30 and +60 min recovery were analysed for plasma IL-6. Overall, IL-6 increased linearly from baseline to +60 min recovery, and a sex difference was found in the IL-6 response, with men peaking earlier than women. These findings confirm a small delayed IL-6 increase after acute laboratory stress, and reveal sex differences in the profile of the IL-6 response.
AB - Interleukin-6 (IL-6), an immune regulator that helps coordinate the inflammatory response, may mediate inflammatory disease exacerbation associated with stress. Twenty men and twenty women completed a single session, comprising baseline (20 min), mental arithmetic task (8 min), and recovery (60 min). Blood samples, taken at baseline, immediately after the task, and at +30 and +60 min recovery were analysed for plasma IL-6. Overall, IL-6 increased linearly from baseline to +60 min recovery, and a sex difference was found in the IL-6 response, with men peaking earlier than women. These findings confirm a small delayed IL-6 increase after acute laboratory stress, and reveal sex differences in the profile of the IL-6 response.
KW - sex differences
KW - interleukin-6
KW - acute stress
U2 - 10.1016/j.biopsycho.2005.06.006
DO - 10.1016/j.biopsycho.2005.06.006
M3 - Article
C2 - 16098655
VL - 71
SP - 236
EP - 239
JO - Biological Psychology
JF - Biological Psychology
ER -