Serum free light chain assessment in monoclonal gammopathy and kidney disease

Colin Hutchison; Kolitha Basnayake; Paul Cockwell

doi:10.1038/nrneph.2009.151

Serum free light chain assessment in monoclonal gammopathy and kidney disease

Colin Hutchison, Kolitha Basnayake, Paul Cockwell

Research output: Contribution to journal › Review article

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Abstract

Abnormalities of immunoglobulin free light chains (FLCs) are frequently present in patients with monoclonal gammopathies and can cause kidney disease. The recent introduction of highly sensitive immunoassays that measure FLCs to levels below those present in normal individuals has provided a new tool for diagnosis and management in this setting. Here, we review the biology of FLC production in health and disease, and the utility of FLC immunoassays in the assessment of monoclonal gammopathies in kidney disease.

Original language	English
Pages (from-to)	621-627
Number of pages	7
Journal	Nature Reviews. Nephrology
Volume	5
Issue number	11
DOIs	https://doi.org/10.1038/nrneph.2009.151
Publication status	Published - 1 Nov 2009

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10.1038/nrneph.2009.151

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abstract = "Abnormalities of immunoglobulin free light chains (FLCs) are frequently present in patients with monoclonal gammopathies and can cause kidney disease. The recent introduction of highly sensitive immunoassays that measure FLCs to levels below those present in normal individuals has provided a new tool for diagnosis and management in this setting. Here, we review the biology of FLC production in health and disease, and the utility of FLC immunoassays in the assessment of monoclonal gammopathies in kidney disease.",

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Serum free light chain assessment in monoclonal gammopathy and kidney disease

Abstract

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