Serrated adenoma prevalence in inflammatory bowel disease surveillance colonoscopy, and characteristics revealed by chromoendoscopy and virtual chromoendoscopy

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Serrated adenoma prevalence in inflammatory bowel disease surveillance colonoscopy, and characteristics revealed by chromoendoscopy and virtual chromoendoscopy. / Iacucci, Marietta; Hassan, Cesare; Fort Gasia, Miriam; Urbanski, Stefan; Gui, Xianyong; Eksteen, Bertus; Eustace, Gregory; Kaplan, Gilaad G; Panaccione, Remo.

In: Canadian Journal of Gastroenterology and Hepatology, Vol. 28, No. 11, 12.2014, p. 589-594.

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Iacucci, Marietta ; Hassan, Cesare ; Fort Gasia, Miriam ; Urbanski, Stefan ; Gui, Xianyong ; Eksteen, Bertus ; Eustace, Gregory ; Kaplan, Gilaad G ; Panaccione, Remo. / Serrated adenoma prevalence in inflammatory bowel disease surveillance colonoscopy, and characteristics revealed by chromoendoscopy and virtual chromoendoscopy. In: Canadian Journal of Gastroenterology and Hepatology. 2014 ; Vol. 28, No. 11. pp. 589-594.

Bibtex

@article{e8b8540c943b452ba4085ab23fad814c,
title = "Serrated adenoma prevalence in inflammatory bowel disease surveillance colonoscopy, and characteristics revealed by chromoendoscopy and virtual chromoendoscopy",
abstract = "BACKGROUND: Sessile or nonpolypoid neoplastic lesions, including sessile serrated adenomas (SSAs), are difficult to detect in patients with inflammatory bowel disease (IBD).OBJECTIVES: To assess the prevalence and endoscopic features of SSA in IBD patients undergoing surveillance colonoscopy using novel endoscopic techniques.METHODS: Histology results of biopsies from a cohort of 87 patients (47 men; median age 51.4 years; median duration of disease 16.9 years; ulcerative colitis [n=40], Crohn disease [n=43], ischemic colitis [n=4]) with longstanding colonic IBD undergoing surveillance colonoscopy were reviewed. Lesions of dysplasia (adenoma-like mass, or dysplasia-associated lesion or mass), SSAs, adenoma-like polyps, hyperplastic polyps and inflammatory polyps were identified. Surveillance colonoscopy using high-definition alone, or with iScan (Pentax, USA) dye-sprayed or virtual chromoendoscopy was performed. Lesion characteristics were described before histological diagnosis.RESULTS: Fourteen SSAs were detected in 87 (11%) IBD patients. The endoscopic characteristics of SSA lesions were: nonpolypoid appearance (86%), predominant localization in the proximal colon (79%), >6 mm in size (79%), cloudy cover (64%), Kudo pit pattern modified type IIO (86%) and irregular spiral vascular pattern (79%). Among the 44 SSAs and hyperplastic polyps found in the present study, the above characteristics of SSA at colonoscopy had a sensitivity of 92.86% (95% CI 66.06% to 98.8%) and specificity of 93.33% (95% CI 77.89% to 98.99%) in predicting a histological diagnosis of SSA (positive predictive value 86.67%, negative predictive value 96.55%).CONCLUSION: SSAs are a common finding at surveillance colonoscopy in IBD and have several characteristic features. Further studies are needed to evaluate the natural history of these lesions in IBD patients.",
keywords = "Adenoma, Adult, Aged, Aged, 80 and over, Colitis, Ulcerative, Colonic Neoplasms, Colonic Polyps, Colonoscopy, Coloring Agents, Crohn Disease, Female, Humans, Male, Middle Aged, Population Surveillance, Predictive Value of Tests, Retrospective Studies, User-Computer Interface, Young Adult, Journal Article, High-definition iScan virtual and dye chromoendoscopy, Inflammatory bowel disease, Sessile serrated adenoma",
author = "Marietta Iacucci and Cesare Hassan and {Fort Gasia}, Miriam and Stefan Urbanski and Xianyong Gui and Bertus Eksteen and Gregory Eustace and Kaplan, {Gilaad G} and Remo Panaccione",
year = "2014",
month = dec,
doi = "10.1155/2014/386540",
language = "English",
volume = "28",
pages = "589--594",
journal = "Canadian Journal of Gastroenterology and Hepatology",
issn = "2291-2789",
publisher = "Pulsus Group Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Serrated adenoma prevalence in inflammatory bowel disease surveillance colonoscopy, and characteristics revealed by chromoendoscopy and virtual chromoendoscopy

AU - Iacucci, Marietta

AU - Hassan, Cesare

AU - Fort Gasia, Miriam

AU - Urbanski, Stefan

AU - Gui, Xianyong

AU - Eksteen, Bertus

AU - Eustace, Gregory

AU - Kaplan, Gilaad G

AU - Panaccione, Remo

PY - 2014/12

Y1 - 2014/12

N2 - BACKGROUND: Sessile or nonpolypoid neoplastic lesions, including sessile serrated adenomas (SSAs), are difficult to detect in patients with inflammatory bowel disease (IBD).OBJECTIVES: To assess the prevalence and endoscopic features of SSA in IBD patients undergoing surveillance colonoscopy using novel endoscopic techniques.METHODS: Histology results of biopsies from a cohort of 87 patients (47 men; median age 51.4 years; median duration of disease 16.9 years; ulcerative colitis [n=40], Crohn disease [n=43], ischemic colitis [n=4]) with longstanding colonic IBD undergoing surveillance colonoscopy were reviewed. Lesions of dysplasia (adenoma-like mass, or dysplasia-associated lesion or mass), SSAs, adenoma-like polyps, hyperplastic polyps and inflammatory polyps were identified. Surveillance colonoscopy using high-definition alone, or with iScan (Pentax, USA) dye-sprayed or virtual chromoendoscopy was performed. Lesion characteristics were described before histological diagnosis.RESULTS: Fourteen SSAs were detected in 87 (11%) IBD patients. The endoscopic characteristics of SSA lesions were: nonpolypoid appearance (86%), predominant localization in the proximal colon (79%), >6 mm in size (79%), cloudy cover (64%), Kudo pit pattern modified type IIO (86%) and irregular spiral vascular pattern (79%). Among the 44 SSAs and hyperplastic polyps found in the present study, the above characteristics of SSA at colonoscopy had a sensitivity of 92.86% (95% CI 66.06% to 98.8%) and specificity of 93.33% (95% CI 77.89% to 98.99%) in predicting a histological diagnosis of SSA (positive predictive value 86.67%, negative predictive value 96.55%).CONCLUSION: SSAs are a common finding at surveillance colonoscopy in IBD and have several characteristic features. Further studies are needed to evaluate the natural history of these lesions in IBD patients.

AB - BACKGROUND: Sessile or nonpolypoid neoplastic lesions, including sessile serrated adenomas (SSAs), are difficult to detect in patients with inflammatory bowel disease (IBD).OBJECTIVES: To assess the prevalence and endoscopic features of SSA in IBD patients undergoing surveillance colonoscopy using novel endoscopic techniques.METHODS: Histology results of biopsies from a cohort of 87 patients (47 men; median age 51.4 years; median duration of disease 16.9 years; ulcerative colitis [n=40], Crohn disease [n=43], ischemic colitis [n=4]) with longstanding colonic IBD undergoing surveillance colonoscopy were reviewed. Lesions of dysplasia (adenoma-like mass, or dysplasia-associated lesion or mass), SSAs, adenoma-like polyps, hyperplastic polyps and inflammatory polyps were identified. Surveillance colonoscopy using high-definition alone, or with iScan (Pentax, USA) dye-sprayed or virtual chromoendoscopy was performed. Lesion characteristics were described before histological diagnosis.RESULTS: Fourteen SSAs were detected in 87 (11%) IBD patients. The endoscopic characteristics of SSA lesions were: nonpolypoid appearance (86%), predominant localization in the proximal colon (79%), >6 mm in size (79%), cloudy cover (64%), Kudo pit pattern modified type IIO (86%) and irregular spiral vascular pattern (79%). Among the 44 SSAs and hyperplastic polyps found in the present study, the above characteristics of SSA at colonoscopy had a sensitivity of 92.86% (95% CI 66.06% to 98.8%) and specificity of 93.33% (95% CI 77.89% to 98.99%) in predicting a histological diagnosis of SSA (positive predictive value 86.67%, negative predictive value 96.55%).CONCLUSION: SSAs are a common finding at surveillance colonoscopy in IBD and have several characteristic features. Further studies are needed to evaluate the natural history of these lesions in IBD patients.

KW - Adenoma

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Colitis, Ulcerative

KW - Colonic Neoplasms

KW - Colonic Polyps

KW - Colonoscopy

KW - Coloring Agents

KW - Crohn Disease

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Population Surveillance

KW - Predictive Value of Tests

KW - Retrospective Studies

KW - User-Computer Interface

KW - Young Adult

KW - Journal Article

KW - High-definition iScan virtual and dye chromoendoscopy

KW - Inflammatory bowel disease

KW - Sessile serrated adenoma

U2 - 10.1155/2014/386540

DO - 10.1155/2014/386540

M3 - Article

C2 - 25575106

VL - 28

SP - 589

EP - 594

JO - Canadian Journal of Gastroenterology and Hepatology

JF - Canadian Journal of Gastroenterology and Hepatology

SN - 2291-2789

IS - 11

ER -