Serrated adenoma prevalence in inflammatory bowel disease surveillance colonoscopy, and characteristics revealed by chromoendoscopy and virtual chromoendoscopy

Research output: Contribution to journalArticlepeer-review

Authors

  • Cesare Hassan
  • Miriam Fort Gasia
  • Stefan Urbanski
  • Xianyong Gui
  • Bertus Eksteen
  • Gregory Eustace
  • Gilaad G Kaplan
  • Remo Panaccione

Colleges, School and Institutes

Abstract

BACKGROUND: Sessile or nonpolypoid neoplastic lesions, including sessile serrated adenomas (SSAs), are difficult to detect in patients with inflammatory bowel disease (IBD).

OBJECTIVES: To assess the prevalence and endoscopic features of SSA in IBD patients undergoing surveillance colonoscopy using novel endoscopic techniques.

METHODS: Histology results of biopsies from a cohort of 87 patients (47 men; median age 51.4 years; median duration of disease 16.9 years; ulcerative colitis [n=40], Crohn disease [n=43], ischemic colitis [n=4]) with longstanding colonic IBD undergoing surveillance colonoscopy were reviewed. Lesions of dysplasia (adenoma-like mass, or dysplasia-associated lesion or mass), SSAs, adenoma-like polyps, hyperplastic polyps and inflammatory polyps were identified. Surveillance colonoscopy using high-definition alone, or with iScan (Pentax, USA) dye-sprayed or virtual chromoendoscopy was performed. Lesion characteristics were described before histological diagnosis.

RESULTS: Fourteen SSAs were detected in 87 (11%) IBD patients. The endoscopic characteristics of SSA lesions were: nonpolypoid appearance (86%), predominant localization in the proximal colon (79%), >6 mm in size (79%), cloudy cover (64%), Kudo pit pattern modified type IIO (86%) and irregular spiral vascular pattern (79%). Among the 44 SSAs and hyperplastic polyps found in the present study, the above characteristics of SSA at colonoscopy had a sensitivity of 92.86% (95% CI 66.06% to 98.8%) and specificity of 93.33% (95% CI 77.89% to 98.99%) in predicting a histological diagnosis of SSA (positive predictive value 86.67%, negative predictive value 96.55%).

CONCLUSION: SSAs are a common finding at surveillance colonoscopy in IBD and have several characteristic features. Further studies are needed to evaluate the natural history of these lesions in IBD patients.

Details

Original languageEnglish
Pages (from-to)589-594
Number of pages6
JournalCanadian Journal of Gastroenterology and Hepatology
Volume28
Issue number11
Publication statusPublished - Dec 2014

Keywords

  • Adenoma, Adult, Aged, Aged, 80 and over, Colitis, Ulcerative, Colonic Neoplasms, Colonic Polyps, Colonoscopy, Coloring Agents, Crohn Disease, Female, Humans, Male, Middle Aged, Population Surveillance, Predictive Value of Tests, Retrospective Studies, User-Computer Interface, Young Adult, Journal Article, High-definition iScan virtual and dye chromoendoscopy, Inflammatory bowel disease, Sessile serrated adenoma