Sequence-specific synthesis of macromolecules using DNA-templated chemistry

Phillip J. Milnes; Mireya L. McKee; Jonathan Bath; Lijiang Song; Eugen Stulz; Andrew J. Turberfield; Rachel K. O'Reilly

doi:10.1039/c2cc31975f

Sequence-specific synthesis of macromolecules using DNA-templated chemistry

Phillip J. Milnes, Mireya L. McKee, Jonathan Bath, Lijiang Song, Eugen Stulz, Andrew J. Turberfield, Rachel K. O'Reilly

Chemistry

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.

Original language	English
Pages (from-to)	5614-5616
Journal	Chemical Communications
Volume	48
Issue number	45
DOIs	https://doi.org/10.1039/c2cc31975f
Publication status	Published - 17 Apr 2012

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AU - Stulz, Eugen

AU - Turberfield, Andrew J.

AU - O'Reilly, Rachel K.

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AB - Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.

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Sequence-specific synthesis of macromolecules using DNA-templated chemistry

Abstract

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