Sensory symptoms in body-focused repetitive behaviors, restless legs syndrome, and Tourette syndrome: An overlap?

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Sensory symptoms in body-focused repetitive behaviors, restless legs syndrome, and Tourette syndrome : An overlap? / Badenoch, James; Searle, Tamara; Watson, Iona; Cavanna, Andrea E.

In: Neuroscience and biobehavioral reviews, Vol. 119, 12.2020, p. 320-332.

Research output: Contribution to journalReview articlepeer-review

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@article{475253a645684fa5a489d470190ea4bb,
title = "Sensory symptoms in body-focused repetitive behaviors, restless legs syndrome, and Tourette syndrome: An overlap?",
abstract = "Tourette syndrome (TS) is a neurodevelopmental condition characterized by multiple tics. Sensory symptoms play a key role in the clinical phenomenology and pathophysiology of TS, as most patients report premonitory urges driving tic expression. Interestingly, sensory symptoms have also been reported in other conditions characterized by repeated behaviors. This review explores the nature of sensory symptoms reported by patients with body focused repetitive behaviors (BFRBs, especially trichotillomania and skin picking disorder) and restless legs syndrome (RLS) in comparison to TS. A sense of mounting inner tension and reinforcement mechanisms driven by gratification and relief on expression of the tic or repetitive behavior appear to be implicated across all conditions. Subjective urges can be temporarily suppressed by patients with TS and selected BFRBs, whereas patients with RLS tend to report dysesthesia more frequently than a suppressible urge to move. The observed similarities in the phenomenology of sensory symptoms across these conditions raise the possibility of a comparable underlying pathophysiology. Preliminary findings suggest an overlap of neural pathways encompassing the insula, basal ganglia (putamen), and posterior cingulate cortex.",
author = "James Badenoch and Tamara Searle and Iona Watson and Cavanna, {Andrea E}",
note = "Copyright {\textcopyright} 2020 Elsevier Ltd. All rights reserved.",
year = "2020",
month = dec,
doi = "10.1016/j.neubiorev.2020.10.008",
language = "English",
volume = "119",
pages = "320--332",
journal = "Neuroscience and biobehavioral reviews",
issn = "0149-7634",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Sensory symptoms in body-focused repetitive behaviors, restless legs syndrome, and Tourette syndrome

T2 - An overlap?

AU - Badenoch, James

AU - Searle, Tamara

AU - Watson, Iona

AU - Cavanna, Andrea E

N1 - Copyright © 2020 Elsevier Ltd. All rights reserved.

PY - 2020/12

Y1 - 2020/12

N2 - Tourette syndrome (TS) is a neurodevelopmental condition characterized by multiple tics. Sensory symptoms play a key role in the clinical phenomenology and pathophysiology of TS, as most patients report premonitory urges driving tic expression. Interestingly, sensory symptoms have also been reported in other conditions characterized by repeated behaviors. This review explores the nature of sensory symptoms reported by patients with body focused repetitive behaviors (BFRBs, especially trichotillomania and skin picking disorder) and restless legs syndrome (RLS) in comparison to TS. A sense of mounting inner tension and reinforcement mechanisms driven by gratification and relief on expression of the tic or repetitive behavior appear to be implicated across all conditions. Subjective urges can be temporarily suppressed by patients with TS and selected BFRBs, whereas patients with RLS tend to report dysesthesia more frequently than a suppressible urge to move. The observed similarities in the phenomenology of sensory symptoms across these conditions raise the possibility of a comparable underlying pathophysiology. Preliminary findings suggest an overlap of neural pathways encompassing the insula, basal ganglia (putamen), and posterior cingulate cortex.

AB - Tourette syndrome (TS) is a neurodevelopmental condition characterized by multiple tics. Sensory symptoms play a key role in the clinical phenomenology and pathophysiology of TS, as most patients report premonitory urges driving tic expression. Interestingly, sensory symptoms have also been reported in other conditions characterized by repeated behaviors. This review explores the nature of sensory symptoms reported by patients with body focused repetitive behaviors (BFRBs, especially trichotillomania and skin picking disorder) and restless legs syndrome (RLS) in comparison to TS. A sense of mounting inner tension and reinforcement mechanisms driven by gratification and relief on expression of the tic or repetitive behavior appear to be implicated across all conditions. Subjective urges can be temporarily suppressed by patients with TS and selected BFRBs, whereas patients with RLS tend to report dysesthesia more frequently than a suppressible urge to move. The observed similarities in the phenomenology of sensory symptoms across these conditions raise the possibility of a comparable underlying pathophysiology. Preliminary findings suggest an overlap of neural pathways encompassing the insula, basal ganglia (putamen), and posterior cingulate cortex.

U2 - 10.1016/j.neubiorev.2020.10.008

DO - 10.1016/j.neubiorev.2020.10.008

M3 - Review article

C2 - 33086129

VL - 119

SP - 320

EP - 332

JO - Neuroscience and biobehavioral reviews

JF - Neuroscience and biobehavioral reviews

SN - 0149-7634

ER -