Sensory gating deficits in the attenuated psychosis syndrome

M Shaikh; A Dutt; MR Broome; AG Vozmediano; S Ranlund; A Diez; O Caseiro; J Lappin; S Amankwa; F Carletti; P Fusar-Poli; M Walshe; MH Hall; O Howes; L Ellett; RM Murray; P McGuire; L Valmaggia; E Bramon

doi:10.1016/j.schres.2014.12.021

Sensory gating deficits in the attenuated psychosis syndrome

M Shaikh, A Dutt, MR Broome, AG Vozmediano, S Ranlund, A Diez, O Caseiro, J Lappin, S Amankwa, F Carletti, P Fusar-Poli, M Walshe, MH Hall, O Howes, L Ellett, RM Murray, P McGuire, L Valmaggia, E Bramon

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Background
Individuals with an “Attenuated Psychosis Syndrome” (APS) have a 20–40% chance of developing a psychotic disorder within two years; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether P50 gating deficits could help to discriminate individuals with APS and also those who are particularly likely to make a transition to psychosis.

Method
36 cases meeting PACE (Personal Assessment and Crisis Evaluation) criteria for the APS, all free of antipsychotics, and 60 controls performed an auditory conditioning–testing experiment while their electroencephalogram was recorded. The P50 ratio and its C–T difference were compared between groups. Subjects received follow-up for up to 2 years to determine their clinical outcome.

Results
The P50 ratio was significantly higher and C–T difference lower in the APS group compared to controls. Of the individuals with APS who completed the follow-up (n = 36), nine (25%) developed psychosis. P50 ratio and the C–T difference did not significantly differ between those individuals who developed psychosis and those who did not within the APS group.

Conclusion
P50 deficits appear to be associated with the pre-clinical phase of psychosis. However, due to the limitations of the study and its sample size, replication in an independent cohort is necessary, to clarify the role of P50 deficits in illness progression and whether this inexpensive and non-invasive EEG marker could be of clinical value in the prediction of psychosis outcomes amongst populations at risk.

Original language	English
Pages (from-to)	277-282
Number of pages	6
Journal	Schizophrenia Research
Volume	161
Issue number	2-3
Early online date	30 Dec 2014
DOIs	https://doi.org/10.1016/j.schres.2014.12.021
Publication status	Published - Feb 2015

Keywords

P50
APS
ERP
EEG
Psychosis
Sensory-gating

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Shaikh, M., Dutt, A., Broome, MR., Vozmediano, AG., Ranlund, S., Diez, A., Caseiro, O., Lappin, J., Amankwa, S., Carletti, F., Fusar-Poli, P., Walshe, M., Hall, MH., Howes, O., Ellett, L., Murray, RM., McGuire, P., Valmaggia, L., & Bramon, E. (2015). Sensory gating deficits in the attenuated psychosis syndrome. Schizophrenia Research, 161(2-3), 277-282. Advance online publication. https://doi.org/10.1016/j.schres.2014.12.021

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title = "Sensory gating deficits in the attenuated psychosis syndrome",

abstract = "BackgroundIndividuals with an “Attenuated Psychosis Syndrome” (APS) have a 20–40% chance of developing a psychotic disorder within two years; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether P50 gating deficits could help to discriminate individuals with APS and also those who are particularly likely to make a transition to psychosis.Method36 cases meeting PACE (Personal Assessment and Crisis Evaluation) criteria for the APS, all free of antipsychotics, and 60 controls performed an auditory conditioning–testing experiment while their electroencephalogram was recorded. The P50 ratio and its C–T difference were compared between groups. Subjects received follow-up for up to 2 years to determine their clinical outcome.ResultsThe P50 ratio was significantly higher and C–T difference lower in the APS group compared to controls. Of the individuals with APS who completed the follow-up (n = 36), nine (25%) developed psychosis. P50 ratio and the C–T difference did not significantly differ between those individuals who developed psychosis and those who did not within the APS group.ConclusionP50 deficits appear to be associated with the pre-clinical phase of psychosis. However, due to the limitations of the study and its sample size, replication in an independent cohort is necessary, to clarify the role of P50 deficits in illness progression and whether this inexpensive and non-invasive EEG marker could be of clinical value in the prediction of psychosis outcomes amongst populations at risk.",

keywords = "P50, APS, ERP, EEG, Psychosis, Sensory-gating",

author = "M Shaikh and A Dutt and MR Broome and AG Vozmediano and S Ranlund and A Diez and O Caseiro and J Lappin and S Amankwa and F Carletti and P Fusar-Poli and M Walshe and MH Hall and O Howes and L Ellett and RM Murray and P McGuire and L Valmaggia and E Bramon",

year = "2015",

month = feb,

doi = "10.1016/j.schres.2014.12.021",

language = "English",

volume = "161",

pages = "277--282",

journal = "Schizophrenia Research",

issn = "0920-9964",

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Shaikh, M, Dutt, A, Broome, MR, Vozmediano, AG, Ranlund, S, Diez, A, Caseiro, O, Lappin, J, Amankwa, S, Carletti, F, Fusar-Poli, P, Walshe, M, Hall, MH, Howes, O, Ellett, L, Murray, RM, McGuire, P, Valmaggia, L & Bramon, E 2015, 'Sensory gating deficits in the attenuated psychosis syndrome', Schizophrenia Research, vol. 161, no. 2-3, pp. 277-282. https://doi.org/10.1016/j.schres.2014.12.021

TY - JOUR

T1 - Sensory gating deficits in the attenuated psychosis syndrome

AU - Shaikh, M

AU - Dutt, A

AU - Broome, MR

AU - Vozmediano, AG

AU - Ranlund, S

AU - Diez, A

AU - Caseiro, O

AU - Lappin, J

AU - Amankwa, S

AU - Carletti, F

AU - Fusar-Poli, P

AU - Walshe, M

AU - Hall, MH

AU - Howes, O

AU - Ellett, L

AU - Murray, RM

AU - McGuire, P

AU - Valmaggia, L

AU - Bramon, E

PY - 2015/2

Y1 - 2015/2

N2 - BackgroundIndividuals with an “Attenuated Psychosis Syndrome” (APS) have a 20–40% chance of developing a psychotic disorder within two years; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether P50 gating deficits could help to discriminate individuals with APS and also those who are particularly likely to make a transition to psychosis.Method36 cases meeting PACE (Personal Assessment and Crisis Evaluation) criteria for the APS, all free of antipsychotics, and 60 controls performed an auditory conditioning–testing experiment while their electroencephalogram was recorded. The P50 ratio and its C–T difference were compared between groups. Subjects received follow-up for up to 2 years to determine their clinical outcome.ResultsThe P50 ratio was significantly higher and C–T difference lower in the APS group compared to controls. Of the individuals with APS who completed the follow-up (n = 36), nine (25%) developed psychosis. P50 ratio and the C–T difference did not significantly differ between those individuals who developed psychosis and those who did not within the APS group.ConclusionP50 deficits appear to be associated with the pre-clinical phase of psychosis. However, due to the limitations of the study and its sample size, replication in an independent cohort is necessary, to clarify the role of P50 deficits in illness progression and whether this inexpensive and non-invasive EEG marker could be of clinical value in the prediction of psychosis outcomes amongst populations at risk.

AB - BackgroundIndividuals with an “Attenuated Psychosis Syndrome” (APS) have a 20–40% chance of developing a psychotic disorder within two years; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether P50 gating deficits could help to discriminate individuals with APS and also those who are particularly likely to make a transition to psychosis.Method36 cases meeting PACE (Personal Assessment and Crisis Evaluation) criteria for the APS, all free of antipsychotics, and 60 controls performed an auditory conditioning–testing experiment while their electroencephalogram was recorded. The P50 ratio and its C–T difference were compared between groups. Subjects received follow-up for up to 2 years to determine their clinical outcome.ResultsThe P50 ratio was significantly higher and C–T difference lower in the APS group compared to controls. Of the individuals with APS who completed the follow-up (n = 36), nine (25%) developed psychosis. P50 ratio and the C–T difference did not significantly differ between those individuals who developed psychosis and those who did not within the APS group.ConclusionP50 deficits appear to be associated with the pre-clinical phase of psychosis. However, due to the limitations of the study and its sample size, replication in an independent cohort is necessary, to clarify the role of P50 deficits in illness progression and whether this inexpensive and non-invasive EEG marker could be of clinical value in the prediction of psychosis outcomes amongst populations at risk.

KW - P50

KW - APS

KW - ERP

KW - EEG

KW - Psychosis

KW - Sensory-gating

U2 - 10.1016/j.schres.2014.12.021

DO - 10.1016/j.schres.2014.12.021

M3 - Article

SN - 0920-9964

VL - 161

SP - 277

EP - 282

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -

Sensory gating deficits in the attenuated psychosis syndrome

Abstract

Keywords

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