Self-Injurious Behavior

Sylvia A. Huisman; Paul Mulder; Janneke Kuijk; Myrthe Kerstholt; Agnies van Eeghen; Arnold Leenders; Ingrid van Balkom; Christopher Oliver; Sigrid Piening; Raoul Hennekam

doi:10.1016/j.neubiorev.2017.02.027

Self-Injurious Behavior

Sylvia A. Huisman, Paul Mulder, Janneke Kuijk, Myrthe Kerstholt, Agnies van Eeghen, Arnold Leenders, Ingrid van Balkom, Christopher Oliver, Sigrid Piening, Raoul Hennekam

Psychology

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

550 Downloads (Pure)

Abstract

Self-injurious behavior (SIB) is a relatively common behavior in individuals with intellectual disabilities (ID). Severe SIB can be devastating and potentially life-threatening.

There is increasing attention for somatic substrates of behavior in genetic syndromes, and growing evidence of an association between pain and discomfort with SIB in people with ID and genetic syndromes.

In this review on SIB phenomenology in people with ID in general and in twelve genetic syndromes, we summarize different SIB characteristics across these etiologically distinct entities and identify influencing factors. We demonstrate that the prevalence of SIB in several well-known genetic intellectual disability syndromes is noticeably higher than in individuals with ID in general, and that characteristics such as age of onset and topographies differ widely across syndromes. Each syndrome is caused by a mutation in a different gene, and this allows detection of several pathways that lead to SIB. Studying these with the behavioral consequences as specific aim will be an important step toward targeted early interventions and prevention.

Original language	English
Pages (from-to)	483-491
Journal	Neuroscience and biobehavioral reviews
Volume	84
Early online date	8 Jul 2017
DOIs	https://doi.org/10.1016/j.neubiorev.2017.02.027
Publication status	Published - Jan 2018

Keywords

Self-injurious behavior
intellectual disability
genes
genetic syndromes
Angelman Syndrome
Cornelia de Lange Syndrome
Cri du Chat Syndrome
Down Syndrome
fragile X Syndrome
Lesch-Nyhan Syndrome
Lowe syndrome
Prader-Willi Syndrome
Rett Syndrome
Smith-Magenis Syndrome
Tuberous Sclerosis Syndrome
Williams-Beuren Syndrome
somatic factors
pain
interdisciplinary study

Access to Document

10.1016/j.neubiorev.2017.02.027Licence: None: All rights reserved

Huisman_et_al_Self-injurious_behaviour_Neuroscience_&_Biobehavioural_Reviews_2017Accepted author manuscript, 742 KBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

http://www.sciencedirect.com/science/article/pii/S0149763416303372Licence: None: All rights reserved

Cite this

@article{bd69816a2c3e42a9b7c89fa3d9e2e262,

title = "Self-Injurious Behavior",

abstract = "Self-injurious behavior (SIB) is a relatively common behavior in individuals with intellectual disabilities (ID). Severe SIB can be devastating and potentially life-threatening.There is increasing attention for somatic substrates of behavior in genetic syndromes, and growing evidence of an association between pain and discomfort with SIB in people with ID and genetic syndromes.In this review on SIB phenomenology in people with ID in general and in twelve genetic syndromes, we summarize different SIB characteristics across these etiologically distinct entities and identify influencing factors. We demonstrate that the prevalence of SIB in several well-known genetic intellectual disability syndromes is noticeably higher than in individuals with ID in general, and that characteristics such as age of onset and topographies differ widely across syndromes. Each syndrome is caused by a mutation in a different gene, and this allows detection of several pathways that lead to SIB. Studying these with the behavioral consequences as specific aim will be an important step toward targeted early interventions and prevention.",

keywords = "Self-injurious behavior , intellectual disability , genes , genetic syndromes , Angelman Syndrome , Cornelia de Lange Syndrome , Cri du Chat Syndrome , Down Syndrome , fragile X Syndrome , Lesch-Nyhan Syndrome , Lowe syndrome , Prader-Willi Syndrome , Rett Syndrome , Smith-Magenis Syndrome , Tuberous Sclerosis Syndrome , Williams-Beuren Syndrome , somatic factors , pain , interdisciplinary study",

author = "Huisman, {Sylvia A.} and Paul Mulder and Janneke Kuijk and Myrthe Kerstholt and {van Eeghen}, Agnies and Arnold Leenders and {van Balkom}, Ingrid and Christopher Oliver and Sigrid Piening and Raoul Hennekam",

year = "2018",

month = jan,

doi = "10.1016/j.neubiorev.2017.02.027",

language = "English",

volume = "84",

pages = "483--491",

journal = "Neuroscience and biobehavioral reviews",

issn = "0149-7634",

publisher = "Elsevier",

}

TY - JOUR

T1 - Self-Injurious Behavior

AU - Huisman, Sylvia A.

AU - Mulder, Paul

AU - Kuijk, Janneke

AU - Kerstholt, Myrthe

AU - van Eeghen, Agnies

AU - Leenders, Arnold

AU - van Balkom, Ingrid

AU - Oliver, Christopher

AU - Piening, Sigrid

AU - Hennekam, Raoul

PY - 2018/1

Y1 - 2018/1

N2 - Self-injurious behavior (SIB) is a relatively common behavior in individuals with intellectual disabilities (ID). Severe SIB can be devastating and potentially life-threatening.There is increasing attention for somatic substrates of behavior in genetic syndromes, and growing evidence of an association between pain and discomfort with SIB in people with ID and genetic syndromes.In this review on SIB phenomenology in people with ID in general and in twelve genetic syndromes, we summarize different SIB characteristics across these etiologically distinct entities and identify influencing factors. We demonstrate that the prevalence of SIB in several well-known genetic intellectual disability syndromes is noticeably higher than in individuals with ID in general, and that characteristics such as age of onset and topographies differ widely across syndromes. Each syndrome is caused by a mutation in a different gene, and this allows detection of several pathways that lead to SIB. Studying these with the behavioral consequences as specific aim will be an important step toward targeted early interventions and prevention.

AB - Self-injurious behavior (SIB) is a relatively common behavior in individuals with intellectual disabilities (ID). Severe SIB can be devastating and potentially life-threatening.There is increasing attention for somatic substrates of behavior in genetic syndromes, and growing evidence of an association between pain and discomfort with SIB in people with ID and genetic syndromes.In this review on SIB phenomenology in people with ID in general and in twelve genetic syndromes, we summarize different SIB characteristics across these etiologically distinct entities and identify influencing factors. We demonstrate that the prevalence of SIB in several well-known genetic intellectual disability syndromes is noticeably higher than in individuals with ID in general, and that characteristics such as age of onset and topographies differ widely across syndromes. Each syndrome is caused by a mutation in a different gene, and this allows detection of several pathways that lead to SIB. Studying these with the behavioral consequences as specific aim will be an important step toward targeted early interventions and prevention.

KW - Self-injurious behavior

KW - intellectual disability

KW - genes

KW - genetic syndromes

KW - Angelman Syndrome

KW - Cornelia de Lange Syndrome

KW - Cri du Chat Syndrome

KW - Down Syndrome

KW - fragile X Syndrome

KW - Lesch-Nyhan Syndrome

KW - Lowe syndrome

KW - Prader-Willi Syndrome

KW - Rett Syndrome

KW - Smith-Magenis Syndrome

KW - Tuberous Sclerosis Syndrome

KW - Williams-Beuren Syndrome

KW - somatic factors

KW - pain

KW - interdisciplinary study

U2 - 10.1016/j.neubiorev.2017.02.027

DO - 10.1016/j.neubiorev.2017.02.027

M3 - Article

SN - 0149-7634

VL - 84

SP - 483

EP - 491

JO - Neuroscience and biobehavioral reviews

JF - Neuroscience and biobehavioral reviews

ER -

Self-Injurious Behavior

Abstract

Keywords

Access to Document

Fingerprint

Cite this