Self-assembly of Zein-based microcarrier system for colon-targeted oral drug delivery

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Self-assembly of Zein-based microcarrier system for colon-targeted oral drug delivery. / Wang, Hongdi; Zhang, Xiaotong; Zhu, Wei ; Jiang, Yanbin; Zhang, Zhibing.

In: Industrial & Engineering Chemistry Research, Vol. 57, No. 38, 26.09.2018, p. 12689-12699.

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Wang, Hongdi ; Zhang, Xiaotong ; Zhu, Wei ; Jiang, Yanbin ; Zhang, Zhibing. / Self-assembly of Zein-based microcarrier system for colon-targeted oral drug delivery. In: Industrial & Engineering Chemistry Research. 2018 ; Vol. 57, No. 38. pp. 12689-12699.

Bibtex

@article{21eb6dd66dc04924bc6015b5170042f0,
title = "Self-assembly of Zein-based microcarrier system for colon-targeted oral drug delivery",
abstract = "The advances in pharmaceutical technology allow for the development of variousregion-selective delivery systems for oral administration to optimize local andsystemic therapy. In this paper, micronization associated with a polymorphmodification approach was proposed for improving the solubility of hydrophobicdrugs for developing a Zein-based colon-targeted delivery system. A microcarrier based on self-assembled structures of Zein was fabricated via a built-in ultrasonic dialysis process, which displayed high payload of a model drug, indomethacin (Indo), with its optimal crystal form. The possible self-assembly mechanism of Zein/Indo forming porous structure in the ultrasonic dialysis process was attributed to the results of intra- and/or inter-molecular interactions between Zein and Indo. The designed microspheres, Zein-Indo@PDA, with a surface coating of polydopamine (PDA) not only rendered them enhanced stability and mechanical resistance, but also hindered the premature drug release at undesired sites. This innovative formulation design may offer better chances of colon-targeted release. ",
keywords = "Zein, self-assembly, colon-targeted, polydopamine, micronization, polymorph modification",
author = "Hongdi Wang and Xiaotong Zhang and Wei Zhu and Yanbin Jiang and Zhibing Zhang",
year = "2018",
month = sep,
day = "26",
doi = "10.1021/acs.iecr.8b02092",
language = "English",
volume = "57",
pages = "12689--12699",
journal = "Industrial & Engineering Chemistry Research",
issn = "0888-5885",
publisher = "American Chemical Society",
number = "38",

}

RIS

TY - JOUR

T1 - Self-assembly of Zein-based microcarrier system for colon-targeted oral drug delivery

AU - Wang, Hongdi

AU - Zhang, Xiaotong

AU - Zhu, Wei

AU - Jiang, Yanbin

AU - Zhang, Zhibing

PY - 2018/9/26

Y1 - 2018/9/26

N2 - The advances in pharmaceutical technology allow for the development of variousregion-selective delivery systems for oral administration to optimize local andsystemic therapy. In this paper, micronization associated with a polymorphmodification approach was proposed for improving the solubility of hydrophobicdrugs for developing a Zein-based colon-targeted delivery system. A microcarrier based on self-assembled structures of Zein was fabricated via a built-in ultrasonic dialysis process, which displayed high payload of a model drug, indomethacin (Indo), with its optimal crystal form. The possible self-assembly mechanism of Zein/Indo forming porous structure in the ultrasonic dialysis process was attributed to the results of intra- and/or inter-molecular interactions between Zein and Indo. The designed microspheres, Zein-Indo@PDA, with a surface coating of polydopamine (PDA) not only rendered them enhanced stability and mechanical resistance, but also hindered the premature drug release at undesired sites. This innovative formulation design may offer better chances of colon-targeted release.

AB - The advances in pharmaceutical technology allow for the development of variousregion-selective delivery systems for oral administration to optimize local andsystemic therapy. In this paper, micronization associated with a polymorphmodification approach was proposed for improving the solubility of hydrophobicdrugs for developing a Zein-based colon-targeted delivery system. A microcarrier based on self-assembled structures of Zein was fabricated via a built-in ultrasonic dialysis process, which displayed high payload of a model drug, indomethacin (Indo), with its optimal crystal form. The possible self-assembly mechanism of Zein/Indo forming porous structure in the ultrasonic dialysis process was attributed to the results of intra- and/or inter-molecular interactions between Zein and Indo. The designed microspheres, Zein-Indo@PDA, with a surface coating of polydopamine (PDA) not only rendered them enhanced stability and mechanical resistance, but also hindered the premature drug release at undesired sites. This innovative formulation design may offer better chances of colon-targeted release.

KW - Zein

KW - self-assembly

KW - colon-targeted

KW - polydopamine

KW - micronization

KW - polymorph modification

U2 - 10.1021/acs.iecr.8b02092

DO - 10.1021/acs.iecr.8b02092

M3 - Article

VL - 57

SP - 12689

EP - 12699

JO - Industrial & Engineering Chemistry Research

JF - Industrial & Engineering Chemistry Research

SN - 0888-5885

IS - 38

ER -