Self-assembly of Zein-based microcarrier system for colon-targeted oral drug delivery

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

External organisations

  • South China University of Technology

Abstract

The advances in pharmaceutical technology allow for the development of various
region-selective delivery systems for oral administration to optimize local and
systemic therapy. In this paper, micronization associated with a polymorph
modification approach was proposed for improving the solubility of hydrophobic
drugs for developing a Zein-based colon-targeted delivery system. A microcarrier based on self-assembled structures of Zein was fabricated via a built-in ultrasonic dialysis process, which displayed high payload of a model drug, indomethacin (Indo), with its optimal crystal form. The possible self-assembly mechanism of Zein/Indo forming porous structure in the ultrasonic dialysis process was attributed to the results of intra- and/or inter-molecular interactions between Zein and Indo. The designed microspheres, Zein-Indo@PDA, with a surface coating of polydopamine (PDA) not only rendered them enhanced stability and mechanical resistance, but also hindered the premature drug release at undesired sites. This innovative formulation design may offer better chances of colon-targeted release.

Details

Original languageEnglish
Pages (from-to)12689-12699
JournalIndustrial & Engineering Chemistry Research
Volume57
Issue number38
Early online date5 Sep 2018
Publication statusPublished - 26 Sep 2018

Keywords

  • Zein, self-assembly, colon-targeted, polydopamine, micronization, polymorph modification