Second messenger modulation of electronic coupling between region CA3 pyramidal cell axons in the rat hippocampus

Simon Gladwell, John Jefferys

    Research output: Contribution to journalArticle

    31 Citations (Scopus)

    Abstract

    Gap junction coupling between hippocampal cell axons has been implicated in high frequency oscillations. We used antidromic activation of region CA3 from the fimbria to test the hypothesis that, if gap junctions exist between CA3 pyramidal cell axons, they should cause cross-talk between cells. Agents known to open gap junctions, including 8-Br-cAMP and forskolin (analogue and activator of the cAMP 2nd messenger system respectively) augmented the antidromic population spike and uncovered fast oscillations in the extracellular field. Increasing 2nd messenger concentration reduced the threshold stimulation for antidromic triggering of action potentials, suggesting an improved capability to conduct the electrical impulse retrogradely to the soma. Our studies support the existence of gap junction coupling between CA3 pyramidal cell axons in the fimbria that can be acutely modulated by 2nd messengers. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)1-4
    Number of pages4
    JournalNeuroscience Letters
    Volume300
    Issue number1
    DOIs
    Publication statusPublished - 2 Mar 2001

    Keywords

    • region CA3
    • gap junctions
    • halothane
    • electrotonic coupling
    • electrophysiology
    • second messenger
    • non-synaptic mechanism
    • cAMP
    • carbenoxolone

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