Season of birth and lung fibrosis among workers exposed to asbestos

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Season of birth and lung fibrosis among workers exposed to asbestos. / Hannu, T; Jaakkola, Maritta; Kivisaari, L; Huuskonen, MS; Vehmas, T.

In: Chronobiology International, Vol. 24, No. 3, 01.05.2007, p. 539-551.

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Hannu, T ; Jaakkola, Maritta ; Kivisaari, L ; Huuskonen, MS ; Vehmas, T. / Season of birth and lung fibrosis among workers exposed to asbestos. In: Chronobiology International. 2007 ; Vol. 24, No. 3. pp. 539-551.

Bibtex

@article{7af60b0ce31a4520b2d28c8c6d936d1b,
title = "Season of birth and lung fibrosis among workers exposed to asbestos",
abstract = "The season of birth has been suggested to influence the development of some diseases, but its role in lung fibrosis seems to not have been studied previously. The aim of this study was to investigate the relation between the season of birth and fibrotic abnormalities as detected radiologically in high-resolution computed tomography (HRCT) among workers exposed to asbestos. The HRCT examination was performed on 528 study subjects. Multiple ordinal regression analysis adjusting for covariates was used to study the relations between birth month or season and radiological fibrosis signs. Subjects born in autumn or winter had more extensive fibrotic changes than those born in spring or summer. This applied to all fibrotic changes, apart from subpleural nodules, but only the overall fibrosis score, septal lines, and honeycombing showed statistically significantly higher values in comparison to spring births. The highest scores were detected among those born in autumn and winter months (September-February). These results suggest that there are differences in fibrotic radiological abnormalities according to the season of birth in adults exposed to asbestos. Several hypotheses could explain the observed findings, including the effects of early respiratory infections, cold temperature, and differences in air pollution levels, as well as some metabolic and hormonal effects.",
keywords = "tomography, season of birth, pulmonary fibrosis, asbestos",
author = "T Hannu and Maritta Jaakkola and L Kivisaari and MS Huuskonen and T Vehmas",
year = "2007",
month = may,
day = "1",
doi = "10.1080/07420520701420725",
language = "English",
volume = "24",
pages = "539--551",
journal = "Chronobiology International",
issn = "0742-0528",
publisher = "Taylor & Francis",
number = "3",

}

RIS

TY - JOUR

T1 - Season of birth and lung fibrosis among workers exposed to asbestos

AU - Hannu, T

AU - Jaakkola, Maritta

AU - Kivisaari, L

AU - Huuskonen, MS

AU - Vehmas, T

PY - 2007/5/1

Y1 - 2007/5/1

N2 - The season of birth has been suggested to influence the development of some diseases, but its role in lung fibrosis seems to not have been studied previously. The aim of this study was to investigate the relation between the season of birth and fibrotic abnormalities as detected radiologically in high-resolution computed tomography (HRCT) among workers exposed to asbestos. The HRCT examination was performed on 528 study subjects. Multiple ordinal regression analysis adjusting for covariates was used to study the relations between birth month or season and radiological fibrosis signs. Subjects born in autumn or winter had more extensive fibrotic changes than those born in spring or summer. This applied to all fibrotic changes, apart from subpleural nodules, but only the overall fibrosis score, septal lines, and honeycombing showed statistically significantly higher values in comparison to spring births. The highest scores were detected among those born in autumn and winter months (September-February). These results suggest that there are differences in fibrotic radiological abnormalities according to the season of birth in adults exposed to asbestos. Several hypotheses could explain the observed findings, including the effects of early respiratory infections, cold temperature, and differences in air pollution levels, as well as some metabolic and hormonal effects.

AB - The season of birth has been suggested to influence the development of some diseases, but its role in lung fibrosis seems to not have been studied previously. The aim of this study was to investigate the relation between the season of birth and fibrotic abnormalities as detected radiologically in high-resolution computed tomography (HRCT) among workers exposed to asbestos. The HRCT examination was performed on 528 study subjects. Multiple ordinal regression analysis adjusting for covariates was used to study the relations between birth month or season and radiological fibrosis signs. Subjects born in autumn or winter had more extensive fibrotic changes than those born in spring or summer. This applied to all fibrotic changes, apart from subpleural nodules, but only the overall fibrosis score, septal lines, and honeycombing showed statistically significantly higher values in comparison to spring births. The highest scores were detected among those born in autumn and winter months (September-February). These results suggest that there are differences in fibrotic radiological abnormalities according to the season of birth in adults exposed to asbestos. Several hypotheses could explain the observed findings, including the effects of early respiratory infections, cold temperature, and differences in air pollution levels, as well as some metabolic and hormonal effects.

KW - tomography

KW - season of birth

KW - pulmonary fibrosis

KW - asbestos

U2 - 10.1080/07420520701420725

DO - 10.1080/07420520701420725

M3 - Article

C2 - 17612950

VL - 24

SP - 539

EP - 551

JO - Chronobiology International

JF - Chronobiology International

SN - 0742-0528

IS - 3

ER -