SDH mutations in cancer

Research output: Contribution to journalReview article

Authors

Colleges, School and Institutes

Abstract

The SDHA, SDHB, SDHC, SDHD genes encode the four subunits of succinate dehydrogenase (SDH; mitochondrial complex II), a mitochondrial enzyme involved in two essential energy-producing metabolic processes of the cell, the Krebs cycle and the electron transport chain. Germline loss-of-function mutations in any of the SDH genes or assembly factor (SDHAF2) cause hereditary paraganglioma/phaeochromocytoma syndrome (HPGL/PCC) through a mechanism which is largely unknown. Owing to the central function of SDH in cellular energy metabolism it is important to understand its role in tumor suppression. Here is reported an overview of genetics, clinical and molecular progress recently performed in understanding the basis of HPGL/PCC tumorigenesis.

Bibliographic note

Under an Elsevier user licence

Details

Original languageEnglish
Pages (from-to)1432-43
Number of pages12
JournalBiochimica et Biophysica Acta
Volume1807
Issue number11
Publication statusPublished - Nov 2011

Keywords

  • Animals, Genes, Tumor Suppressor, Humans, Isoenzymes/chemistry, Mitochondria/enzymology, Mutation, Neoplasms/enzymology, Protein Subunits/chemistry, Succinate Dehydrogenase/chemistry