Scalable synthesis of multicolour conjugated polymer nanoparticles via Suzuki-Miyaura polymerisation in a miniemulsion and application in bioimaging

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Scalable synthesis of multicolour conjugated polymer nanoparticles via Suzuki-Miyaura polymerisation in a miniemulsion and application in bioimaging. / Behrendt, Jonathan M.; Guzman, Jair A. Esquivel; Purdie, Laura; Willcock, Helen; Morrison, John J.; Foster, Andrew B.; O'Reilly, Rachel K.; McCairn, Mark C.; Turner, Michael L.

In: Reactive and Functional Polymers, Vol. 107, 01.10.2016, p. 69-77.

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Behrendt, Jonathan M. ; Guzman, Jair A. Esquivel ; Purdie, Laura ; Willcock, Helen ; Morrison, John J. ; Foster, Andrew B. ; O'Reilly, Rachel K. ; McCairn, Mark C. ; Turner, Michael L. / Scalable synthesis of multicolour conjugated polymer nanoparticles via Suzuki-Miyaura polymerisation in a miniemulsion and application in bioimaging. In: Reactive and Functional Polymers. 2016 ; Vol. 107. pp. 69-77.

Bibtex

@article{07d45b16ab764a3c962f52c5466266fe,
title = "Scalable synthesis of multicolour conjugated polymer nanoparticles via Suzuki-Miyaura polymerisation in a miniemulsion and application in bioimaging",
abstract = "Suzuki cross-coupling polymerisation of aryldibromides and aryldiboronate esters in a sodium dodecyl sulfate (SDS)-stabilised miniemulsion provides a versatile and direct route to fluorescent conjugated polymer nanoparticles (CPNs). These nanoparticles have a conjugated backbone based on poly(9,9-dioctylfluorene) (PFO), however, significant structural diversity is introduced by incorporation of electron withdrawing, heterocyclic comonomers (5–50 mol.%) in order to tune the emission wavelengths from blue to far-red/near-infrared. The robust nature of the polymerisation methodology allows for rapid assessment of the relationship between polymer composition, chain morphology and optical properties of the resultant CPNs. Moreover, the CPNs (after a simple and rapid purification step) can be used directly in fluorescence-based intracellular labelling experiments (in HCT116 cells), in which they display low cytotoxicity at biologically-useful concentrations.",
keywords = "conjugated polymer nanoparticles, miniemulsion, Suzuki-Miyaura polymerisation, scaleable, bioimaging",
author = "Behrendt, {Jonathan M.} and Guzman, {Jair A. Esquivel} and Laura Purdie and Helen Willcock and Morrison, {John J.} and Foster, {Andrew B.} and O'Reilly, {Rachel K.} and McCairn, {Mark C.} and Turner, {Michael L.}",
year = "2016",
month = oct,
day = "1",
doi = "10.1016/j.reactfunctpolym.2016.08.006",
language = "English",
volume = "107",
pages = "69--77",
journal = "Reactive and Functional Polymers",
issn = "1381-5148",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Scalable synthesis of multicolour conjugated polymer nanoparticles via Suzuki-Miyaura polymerisation in a miniemulsion and application in bioimaging

AU - Behrendt, Jonathan M.

AU - Guzman, Jair A. Esquivel

AU - Purdie, Laura

AU - Willcock, Helen

AU - Morrison, John J.

AU - Foster, Andrew B.

AU - O'Reilly, Rachel K.

AU - McCairn, Mark C.

AU - Turner, Michael L.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Suzuki cross-coupling polymerisation of aryldibromides and aryldiboronate esters in a sodium dodecyl sulfate (SDS)-stabilised miniemulsion provides a versatile and direct route to fluorescent conjugated polymer nanoparticles (CPNs). These nanoparticles have a conjugated backbone based on poly(9,9-dioctylfluorene) (PFO), however, significant structural diversity is introduced by incorporation of electron withdrawing, heterocyclic comonomers (5–50 mol.%) in order to tune the emission wavelengths from blue to far-red/near-infrared. The robust nature of the polymerisation methodology allows for rapid assessment of the relationship between polymer composition, chain morphology and optical properties of the resultant CPNs. Moreover, the CPNs (after a simple and rapid purification step) can be used directly in fluorescence-based intracellular labelling experiments (in HCT116 cells), in which they display low cytotoxicity at biologically-useful concentrations.

AB - Suzuki cross-coupling polymerisation of aryldibromides and aryldiboronate esters in a sodium dodecyl sulfate (SDS)-stabilised miniemulsion provides a versatile and direct route to fluorescent conjugated polymer nanoparticles (CPNs). These nanoparticles have a conjugated backbone based on poly(9,9-dioctylfluorene) (PFO), however, significant structural diversity is introduced by incorporation of electron withdrawing, heterocyclic comonomers (5–50 mol.%) in order to tune the emission wavelengths from blue to far-red/near-infrared. The robust nature of the polymerisation methodology allows for rapid assessment of the relationship between polymer composition, chain morphology and optical properties of the resultant CPNs. Moreover, the CPNs (after a simple and rapid purification step) can be used directly in fluorescence-based intracellular labelling experiments (in HCT116 cells), in which they display low cytotoxicity at biologically-useful concentrations.

KW - conjugated polymer nanoparticles

KW - miniemulsion

KW - Suzuki-Miyaura polymerisation

KW - scaleable

KW - bioimaging

U2 - 10.1016/j.reactfunctpolym.2016.08.006

DO - 10.1016/j.reactfunctpolym.2016.08.006

M3 - Article

VL - 107

SP - 69

EP - 77

JO - Reactive and Functional Polymers

JF - Reactive and Functional Polymers

SN - 1381-5148

ER -