Runx1 Structure and Function in Blood Cell Development

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Standard

Runx1 Structure and Function in Blood Cell Development. / Bonifer, Constanze; Levantini, Elena; Kouskoff, Valerie; Lacaud, Georges.

RUNX Proteins in Development and Cancer. ed. / Yoram Groner; Yoshiaki Ito; Paul Liu; James C. Neil; Nancy A. Speck; Andre van Wijnen. Springer, 2017. p. 65-81 (Advances in Experimental Medicine and Biology; Vol. 962, No. Book Part III).

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Harvard

Bonifer, C, Levantini, E, Kouskoff, V & Lacaud, G 2017, Runx1 Structure and Function in Blood Cell Development. in Y Groner, Y Ito, P Liu, JC Neil, NA Speck & A van Wijnen (eds), RUNX Proteins in Development and Cancer. Advances in Experimental Medicine and Biology, no. Book Part III, vol. 962, Springer, pp. 65-81. https://doi.org/10.1007/978-981-10-3233-2_5

APA

Bonifer, C., Levantini, E., Kouskoff, V., & Lacaud, G. (2017). Runx1 Structure and Function in Blood Cell Development. In Y. Groner, Y. Ito, P. Liu, J. C. Neil, N. A. Speck, & A. van Wijnen (Eds.), RUNX Proteins in Development and Cancer (pp. 65-81). (Advances in Experimental Medicine and Biology; Vol. 962, No. Book Part III). Springer. https://doi.org/10.1007/978-981-10-3233-2_5

Vancouver

Bonifer C, Levantini E, Kouskoff V, Lacaud G. Runx1 Structure and Function in Blood Cell Development. In Groner Y, Ito Y, Liu P, Neil JC, Speck NA, van Wijnen A, editors, RUNX Proteins in Development and Cancer. Springer. 2017. p. 65-81. (Advances in Experimental Medicine and Biology; Book Part III). https://doi.org/10.1007/978-981-10-3233-2_5

Author

Bonifer, Constanze ; Levantini, Elena ; Kouskoff, Valerie ; Lacaud, Georges. / Runx1 Structure and Function in Blood Cell Development. RUNX Proteins in Development and Cancer. editor / Yoram Groner ; Yoshiaki Ito ; Paul Liu ; James C. Neil ; Nancy A. Speck ; Andre van Wijnen. Springer, 2017. pp. 65-81 (Advances in Experimental Medicine and Biology; Book Part III).

Bibtex

@inbook{f568dfbdb62f4d9e86c05b064fa60c45,
title = "Runx1 Structure and Function in Blood Cell Development",
abstract = "RUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors. Furthermore, we outline how RUNX1 works together with other factors to reshape the epigenetic landscape and the three-dimensional structure of gene loci within the nucleus. Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies.",
keywords = "RUNX1, Blood cell development, Isoforms, Regulation of RUNX1 activity, Chromatin structure, Transcriptional networks, Leukaemia",
author = "Constanze Bonifer and Elena Levantini and Valerie Kouskoff and Georges Lacaud",
year = "2017",
month = mar,
day = "16",
doi = "10.1007/978-981-10-3233-2_5",
language = "English",
isbn = "978-9811032318",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer",
number = "Book Part III",
pages = "65--81",
editor = "Yoram Groner and Yoshiaki Ito and Liu, {Paul } and Neil, {James C.} and Speck, {Nancy A.} and {van Wijnen}, Andre",
booktitle = "RUNX Proteins in Development and Cancer",

}

RIS

TY - CHAP

T1 - Runx1 Structure and Function in Blood Cell Development

AU - Bonifer, Constanze

AU - Levantini, Elena

AU - Kouskoff, Valerie

AU - Lacaud, Georges

PY - 2017/3/16

Y1 - 2017/3/16

N2 - RUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors. Furthermore, we outline how RUNX1 works together with other factors to reshape the epigenetic landscape and the three-dimensional structure of gene loci within the nucleus. Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies.

AB - RUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors. Furthermore, we outline how RUNX1 works together with other factors to reshape the epigenetic landscape and the three-dimensional structure of gene loci within the nucleus. Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies.

KW - RUNX1

KW - Blood cell development

KW - Isoforms

KW - Regulation of RUNX1 activity

KW - Chromatin structure

KW - Transcriptional networks

KW - Leukaemia

U2 - 10.1007/978-981-10-3233-2_5

DO - 10.1007/978-981-10-3233-2_5

M3 - Chapter (peer-reviewed)

C2 - 28299651

SN - 978-9811032318

T3 - Advances in Experimental Medicine and Biology

SP - 65

EP - 81

BT - RUNX Proteins in Development and Cancer

A2 - Groner, Yoram

A2 - Ito, Yoshiaki

A2 - Liu, Paul

A2 - Neil, James C.

A2 - Speck, Nancy A.

A2 - van Wijnen, Andre

PB - Springer

ER -