Runx1 Structure and Function in Blood Cell Development

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Authors

Colleges, School and Institutes

External organisations

  • Beth Israel Diaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • University of Manchester

Abstract

RUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors. Furthermore, we outline how RUNX1 works together with other factors to reshape the epigenetic landscape and the three-dimensional structure of gene loci within the nucleus. Finally, we review how aberrant forms of RUNX1 deregulate blood cell development and cause hematopoietic malignancies.

Details

Original languageEnglish
Title of host publicationRUNX Proteins in Development and Cancer
EditorsYoram Groner, Yoshiaki Ito, Paul Liu, James C. Neil, Nancy A. Speck, Andre van Wijnen
Publication statusPublished - 16 Mar 2017

Publication series

NameAdvances in Experimental Medicine and Biology
NumberBook Part III
Volume962
ISSN (Print)0065-2598

Keywords

  • RUNX1, Blood cell development, Isoforms, Regulation of RUNX1 activity, Chromatin structure, Transcriptional networks, Leukaemia