Runx proteins regulate Foxp3 expression

Research output: Contribution to journalArticle

Standard

Runx proteins regulate Foxp3 expression. / Bruno, L; Mazzarella, L; Hoogenkamp, Maarten; Hertweck, A; Cobb, BS; Sauer, S; Hadjur, S; Leleu, M; Naoe, Y; Telfer, JC; Bonifer, Constanze; Taniuchi, I; Fisher, AG; Merkenschlager, M.

In: The Journal of Experimental Medicine, Vol. 206, No. 11, 01.10.2009, p. 2329-2337.

Research output: Contribution to journalArticle

Harvard

Bruno, L, Mazzarella, L, Hoogenkamp, M, Hertweck, A, Cobb, BS, Sauer, S, Hadjur, S, Leleu, M, Naoe, Y, Telfer, JC, Bonifer, C, Taniuchi, I, Fisher, AG & Merkenschlager, M 2009, 'Runx proteins regulate Foxp3 expression', The Journal of Experimental Medicine, vol. 206, no. 11, pp. 2329-2337. https://doi.org/10.1084/jem.20090226

APA

Bruno, L., Mazzarella, L., Hoogenkamp, M., Hertweck, A., Cobb, BS., Sauer, S., Hadjur, S., Leleu, M., Naoe, Y., Telfer, JC., Bonifer, C., Taniuchi, I., Fisher, AG., & Merkenschlager, M. (2009). Runx proteins regulate Foxp3 expression. The Journal of Experimental Medicine, 206(11), 2329-2337. https://doi.org/10.1084/jem.20090226

Vancouver

Bruno L, Mazzarella L, Hoogenkamp M, Hertweck A, Cobb BS, Sauer S et al. Runx proteins regulate Foxp3 expression. The Journal of Experimental Medicine. 2009 Oct 1;206(11):2329-2337. https://doi.org/10.1084/jem.20090226

Author

Bruno, L ; Mazzarella, L ; Hoogenkamp, Maarten ; Hertweck, A ; Cobb, BS ; Sauer, S ; Hadjur, S ; Leleu, M ; Naoe, Y ; Telfer, JC ; Bonifer, Constanze ; Taniuchi, I ; Fisher, AG ; Merkenschlager, M. / Runx proteins regulate Foxp3 expression. In: The Journal of Experimental Medicine. 2009 ; Vol. 206, No. 11. pp. 2329-2337.

Bibtex

@article{2c47d664961142ee967add2306875f48,
title = "Runx proteins regulate Foxp3 expression",
abstract = "Runx proteins are essential for hematopoiesis and play an important role in T cell development by regulating key target genes, such as CD4 and CD8 as well as lymphokine genes, during the specialization of naive CD4 T cells into distinct T helper subsets. In regulatory T (T reg) cells, the signature transcription factor Foxp3 interacts with and modulates the function of several other DNA binding proteins, including Runx family members, at the protein level. We show that Runx proteins also regulate the initiation and the maintenance of Foxp3 gene expression in CD4 T cells. Full-length Runx promoted the de novo expression of Foxp3 during inducible T reg cell differentiation, whereas the isolated dominant-negative Runt DNA binding domain antagonized de novo Foxp3 expression. Foxp3 expression in natural T reg cells remained dependent on Runx proteins and correlated with the binding of Runx/core-binding factor. to regulatory elements within the Foxp3 locus. Our data show that Runx and Foxp3 are components of a feed-forward loop in which Runx proteins contribute to the expression of Foxp3 and cooperate with Foxp3 proteins to regulate the expression of downstream target genes.",
keywords = "runx proteins",
author = "L Bruno and L Mazzarella and Maarten Hoogenkamp and A Hertweck and BS Cobb and S Sauer and S Hadjur and M Leleu and Y Naoe and JC Telfer and Constanze Bonifer and I Taniuchi and AG Fisher and M Merkenschlager",
year = "2009",
month = oct,
day = "1",
doi = "10.1084/jem.20090226",
language = "English",
volume = "206",
pages = "2329--2337",
journal = "The Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "11",

}

RIS

TY - JOUR

T1 - Runx proteins regulate Foxp3 expression

AU - Bruno, L

AU - Mazzarella, L

AU - Hoogenkamp, Maarten

AU - Hertweck, A

AU - Cobb, BS

AU - Sauer, S

AU - Hadjur, S

AU - Leleu, M

AU - Naoe, Y

AU - Telfer, JC

AU - Bonifer, Constanze

AU - Taniuchi, I

AU - Fisher, AG

AU - Merkenschlager, M

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Runx proteins are essential for hematopoiesis and play an important role in T cell development by regulating key target genes, such as CD4 and CD8 as well as lymphokine genes, during the specialization of naive CD4 T cells into distinct T helper subsets. In regulatory T (T reg) cells, the signature transcription factor Foxp3 interacts with and modulates the function of several other DNA binding proteins, including Runx family members, at the protein level. We show that Runx proteins also regulate the initiation and the maintenance of Foxp3 gene expression in CD4 T cells. Full-length Runx promoted the de novo expression of Foxp3 during inducible T reg cell differentiation, whereas the isolated dominant-negative Runt DNA binding domain antagonized de novo Foxp3 expression. Foxp3 expression in natural T reg cells remained dependent on Runx proteins and correlated with the binding of Runx/core-binding factor. to regulatory elements within the Foxp3 locus. Our data show that Runx and Foxp3 are components of a feed-forward loop in which Runx proteins contribute to the expression of Foxp3 and cooperate with Foxp3 proteins to regulate the expression of downstream target genes.

AB - Runx proteins are essential for hematopoiesis and play an important role in T cell development by regulating key target genes, such as CD4 and CD8 as well as lymphokine genes, during the specialization of naive CD4 T cells into distinct T helper subsets. In regulatory T (T reg) cells, the signature transcription factor Foxp3 interacts with and modulates the function of several other DNA binding proteins, including Runx family members, at the protein level. We show that Runx proteins also regulate the initiation and the maintenance of Foxp3 gene expression in CD4 T cells. Full-length Runx promoted the de novo expression of Foxp3 during inducible T reg cell differentiation, whereas the isolated dominant-negative Runt DNA binding domain antagonized de novo Foxp3 expression. Foxp3 expression in natural T reg cells remained dependent on Runx proteins and correlated with the binding of Runx/core-binding factor. to regulatory elements within the Foxp3 locus. Our data show that Runx and Foxp3 are components of a feed-forward loop in which Runx proteins contribute to the expression of Foxp3 and cooperate with Foxp3 proteins to regulate the expression of downstream target genes.

KW - runx proteins

U2 - 10.1084/jem.20090226

DO - 10.1084/jem.20090226

M3 - Article

C2 - 19841090

VL - 206

SP - 2329

EP - 2337

JO - The Journal of Experimental Medicine

JF - The Journal of Experimental Medicine

SN - 0022-1007

IS - 11

ER -