RSV epidemiology in a birth cohort in Kilifi District, Kenya: infection in the first year of life

Research output: Contribution to journalArticle

Authors

  • DJ Nokes
  • EA Okiro
  • M Ngama
  • LJ White
  • R Ochola
  • GF Medley

Abstract

We report estimates of incidence of respiratory syncytial virus (RSV) infection during the first year of life for a birth cohort from rural, coastal Kenya. A total of 338 recruits born between 21 January 2002 and 30 May 2002 were monitored for symptoms of respiratory infection by home visits and hospital referrals. Nasal washings were screened by use of immunofluorescence. From 311 child-years of observation (cyo), 133 RSV infections were found, of which 48 were lower respiratory tract infections (LRTIs) and 31 were severe LRTIs, resulting in 4 hospital admissions. There were 121 primary RSV infections (248 cyo), of which 45 were LRTIs and 30 were severe LRTIs, resulting in 4 hospital admissions; there was no association with age. RSV contributed significantly to total LRTI disease in this vaccine-target group.

Details

Original languageEnglish
Pages (from-to)1828-32
Number of pages5
JournalThe Journal of Infectious Diseases
Volume190
Early online date8 Oct 2004
Publication statusPublished - 15 Nov 2004