Role of supraspinal vasopressin neurones in the effects of atrial natriuretic peptide on sympathetic nerve activity

Research output: Contribution to journalReview article

Authors

Colleges, School and Institutes

Abstract

The aim of the present study was to determine if paraventricular-spinal vasopressin neurones participate in the sympatho-inhibitory effects of systemically administered atrial natriuretic peptide (ANP) on renal sympathetic nerve activity (RSNA). Experiments were carried out on male Sprague-Dawley rats anesthetized with 1.3 g/kg urethane. Changes in mean arterial pressure (mm Hg), heart rate (beats per minute) and RSNA (%) were measured following intravenous bolus administration of ANP (250 ng, 500 ng and 5 mu g). Intrathecal application of selective V-1a receptor antagonist was performed to test for the involvement of supraspinal vasopressin pathways in mediating the effect on sympathetic outflow evoked by intravenous ANP administration. The results obtained demonstrated that both low and high doses of ANP caused renal sympathoinhibition (250 ng; -7.5 +/- 1%, 500 ng; -14.2 +/- 1%, 5 mu g; -16.4 +/- 2%), concomitant with vasodilation and bradycardia. After spinal vasopressin receptor blockade, the inhibitory effects of ANP were prevented and there was a small renal sympatho-excitation (250 ng; + 1.7 +/- 0.2%. 500 ng; + 6.1 +/- 0.03%. 5 mu g; + 8.0 +/- 0.03%, P

Details

Original languageEnglish
Pages (from-to)50-54
Number of pages5
JournalAutonomic Neuroscience
Volume148
Issue number1-2
Publication statusPublished - 1 Jun 2009

Keywords

  • Brain neuropeptides, Renal sympathetic nerve activity, Natriuretic factors