Role of minimal (measurable) residual disease assessment in older patients with acute myeloid leukemia

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Role of minimal (measurable) residual disease assessment in older patients with acute myeloid leukemia. / Buccisano, Francesco; Dillon, Richard; Freeman, Sylvie D; Venditti, Adriano.

In: Cancers, Vol. 10, No. 7, 215, 01.07.2018.

Research output: Contribution to journalReview articlepeer-review

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Buccisano, Francesco ; Dillon, Richard ; Freeman, Sylvie D ; Venditti, Adriano. / Role of minimal (measurable) residual disease assessment in older patients with acute myeloid leukemia. In: Cancers. 2018 ; Vol. 10, No. 7.

Bibtex

@article{b65698ac9e0546fe9d919e20b3a1b313,
title = "Role of minimal (measurable) residual disease assessment in older patients with acute myeloid leukemia",
abstract = "Minimal (or measurable) residual (MRD) disease provides a biomarker of response quality for which there is robust validation in the context of modern intensive treatment for younger patients with Acute Myeloid Leukemia (AML). Nevertheless, it remains a relatively unexplored area in older patients with AML. The lack of progress in this field can be attributed to two main reasons. First, physicians have a general reluctance to submitting older adults to intensive chemotherapy due to their frailty and to the unfavourable biological disease profile predicting a poor outcome following conventional chemotherapy. Second, with the increasing use of low-intensity therapies (i.e., hypomethylating agents) differing from conventional drugs in mechanism of action and dynamics of response, there has been concomitant skepticism that these schedules can produce deep hematological responses. Furthermore, age dependent differences in disease biology also contribute to uncertainty on the prognostic/predictive impact in older adults of certain genetic abnormalities including those validated for MRD monitoring in younger patients. This review examines the evidence for the role of MRD as a prognosticator in older AML, together with the possible pitfalls of MRD evaluation in older age.",
keywords = "older AML, multiparametric flow-cytometry, RT-qPCR",
author = "Francesco Buccisano and Richard Dillon and Freeman, {Sylvie D} and Adriano Venditti",
year = "2018",
month = jul,
day = "1",
doi = "10.3390/cancers10070215",
language = "English",
volume = "10",
journal = "Cancers",
issn = "2072-6694",
publisher = "MDPI",
number = "7",

}

RIS

TY - JOUR

T1 - Role of minimal (measurable) residual disease assessment in older patients with acute myeloid leukemia

AU - Buccisano, Francesco

AU - Dillon, Richard

AU - Freeman, Sylvie D

AU - Venditti, Adriano

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Minimal (or measurable) residual (MRD) disease provides a biomarker of response quality for which there is robust validation in the context of modern intensive treatment for younger patients with Acute Myeloid Leukemia (AML). Nevertheless, it remains a relatively unexplored area in older patients with AML. The lack of progress in this field can be attributed to two main reasons. First, physicians have a general reluctance to submitting older adults to intensive chemotherapy due to their frailty and to the unfavourable biological disease profile predicting a poor outcome following conventional chemotherapy. Second, with the increasing use of low-intensity therapies (i.e., hypomethylating agents) differing from conventional drugs in mechanism of action and dynamics of response, there has been concomitant skepticism that these schedules can produce deep hematological responses. Furthermore, age dependent differences in disease biology also contribute to uncertainty on the prognostic/predictive impact in older adults of certain genetic abnormalities including those validated for MRD monitoring in younger patients. This review examines the evidence for the role of MRD as a prognosticator in older AML, together with the possible pitfalls of MRD evaluation in older age.

AB - Minimal (or measurable) residual (MRD) disease provides a biomarker of response quality for which there is robust validation in the context of modern intensive treatment for younger patients with Acute Myeloid Leukemia (AML). Nevertheless, it remains a relatively unexplored area in older patients with AML. The lack of progress in this field can be attributed to two main reasons. First, physicians have a general reluctance to submitting older adults to intensive chemotherapy due to their frailty and to the unfavourable biological disease profile predicting a poor outcome following conventional chemotherapy. Second, with the increasing use of low-intensity therapies (i.e., hypomethylating agents) differing from conventional drugs in mechanism of action and dynamics of response, there has been concomitant skepticism that these schedules can produce deep hematological responses. Furthermore, age dependent differences in disease biology also contribute to uncertainty on the prognostic/predictive impact in older adults of certain genetic abnormalities including those validated for MRD monitoring in younger patients. This review examines the evidence for the role of MRD as a prognosticator in older AML, together with the possible pitfalls of MRD evaluation in older age.

KW - older AML

KW - multiparametric flow-cytometry

KW - RT-qPCR

U2 - 10.3390/cancers10070215

DO - 10.3390/cancers10070215

M3 - Review article

C2 - 29949858

VL - 10

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 7

M1 - 215

ER -