Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection

Alison R Kerr; June J Irvine; Jennifer J Search; Neill A Gingles; Aras Kadioglu; Peter W Andrew; William L McPheat; Charles G Booth; Tim J Mitchell

Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection

Alison R Kerr, June J Irvine, Jennifer J Search, Neill A Gingles, Aras Kadioglu, Peter W Andrew, William L McPheat, Charles G Booth, Tim J Mitchell

Microbiology and Infection

Research output: Contribution to journal › Article › peer-review

92 Citations (Scopus)

Abstract

Variations in the host response during pneumonia caused by Streptococcus pneumoniae in susceptible (CBA/Ca) and resistant (BALB/c) inbred mouse strains were investigated. Significant differences were detected in survival time, core body temperature, lung-associated and systemic bacterial loads, mast cell numbers, magnitude and location of cytokine production, lung disruption, and ability of isolated lung cells to release the cytokine tumor necrosis factor (TNF) alpha in vitro. Overall, the results indicate that the reduced capacity of CBA/Ca mice to induce rapid TNF activity within the airways following infection with S. pneumoniae may be a factor in their elevated susceptibility to pneumococcal pneumonia.

Original language	English
Pages (from-to)	1547-57
Number of pages	11
Journal	Infection and Immunity
Volume	70
Issue number	3
Publication status	Published - Mar 2002

Keywords

Animals
Cell Count
Cytokines
Disease Susceptibility
Female
Hypothermia
Inflammation Mediators
Lung
Mast Cells
Mice
Mice, Inbred BALB C
Mice, Inbred CBA
Nose Diseases
Pneumonia, Pneumococcal
Species Specificity
Tumor Necrosis Factor-alpha

Cite this

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title = "Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection",

abstract = "Variations in the host response during pneumonia caused by Streptococcus pneumoniae in susceptible (CBA/Ca) and resistant (BALB/c) inbred mouse strains were investigated. Significant differences were detected in survival time, core body temperature, lung-associated and systemic bacterial loads, mast cell numbers, magnitude and location of cytokine production, lung disruption, and ability of isolated lung cells to release the cytokine tumor necrosis factor (TNF) alpha in vitro. Overall, the results indicate that the reduced capacity of CBA/Ca mice to induce rapid TNF activity within the airways following infection with S. pneumoniae may be a factor in their elevated susceptibility to pneumococcal pneumonia.",

keywords = "Animals, Cell Count, Cytokines, Disease Susceptibility, Female, Hypothermia, Inflammation Mediators, Lung, Mast Cells, Mice, Mice, Inbred BALB C, Mice, Inbred CBA, Nose Diseases, Pneumonia, Pneumococcal, Species Specificity, Tumor Necrosis Factor-alpha",

author = "Kerr, {Alison R} and Irvine, {June J} and Search, {Jennifer J} and Gingles, {Neill A} and Aras Kadioglu and Andrew, {Peter W} and McPheat, {William L} and Booth, {Charles G} and Mitchell, {Tim J}",

year = "2002",

month = mar,

language = "English",

volume = "70",

pages = "1547--57",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "3",

}

TY - JOUR

T1 - Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection

AU - Kerr, Alison R

AU - Irvine, June J

AU - Search, Jennifer J

AU - Gingles, Neill A

AU - Kadioglu, Aras

AU - Andrew, Peter W

AU - McPheat, William L

AU - Booth, Charles G

AU - Mitchell, Tim J

PY - 2002/3

Y1 - 2002/3

N2 - Variations in the host response during pneumonia caused by Streptococcus pneumoniae in susceptible (CBA/Ca) and resistant (BALB/c) inbred mouse strains were investigated. Significant differences were detected in survival time, core body temperature, lung-associated and systemic bacterial loads, mast cell numbers, magnitude and location of cytokine production, lung disruption, and ability of isolated lung cells to release the cytokine tumor necrosis factor (TNF) alpha in vitro. Overall, the results indicate that the reduced capacity of CBA/Ca mice to induce rapid TNF activity within the airways following infection with S. pneumoniae may be a factor in their elevated susceptibility to pneumococcal pneumonia.

AB - Variations in the host response during pneumonia caused by Streptococcus pneumoniae in susceptible (CBA/Ca) and resistant (BALB/c) inbred mouse strains were investigated. Significant differences were detected in survival time, core body temperature, lung-associated and systemic bacterial loads, mast cell numbers, magnitude and location of cytokine production, lung disruption, and ability of isolated lung cells to release the cytokine tumor necrosis factor (TNF) alpha in vitro. Overall, the results indicate that the reduced capacity of CBA/Ca mice to induce rapid TNF activity within the airways following infection with S. pneumoniae may be a factor in their elevated susceptibility to pneumococcal pneumonia.

KW - Animals

KW - Cell Count

KW - Cytokines

KW - Disease Susceptibility

KW - Female

KW - Hypothermia

KW - Inflammation Mediators

KW - Lung

KW - Mast Cells

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Inbred CBA

KW - Nose Diseases

KW - Pneumonia, Pneumococcal

KW - Species Specificity

KW - Tumor Necrosis Factor-alpha

M3 - Article

C2 - 11854243

SN - 0019-9567

VL - 70

SP - 1547

EP - 1557

JO - Infection and Immunity

JF - Infection and Immunity

IS - 3

ER -

Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection

Abstract

Keywords

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