Abstract
B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.
Original language | English |
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Article number | 429 |
Journal | F1000Research |
Volume | 7 |
DOIs | |
Publication status | Published - 6 Apr 2018 |
Keywords
- B cell development
- B cell differentiation
- B cell receptor
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine (miscellaneous)