Role of B-cell receptors for B-cell development and antigen-induced differentiation

Research output: Contribution to journalReview articlepeer-review

Authors

Colleges, School and Institutes

Abstract

B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation.

Details

Original languageEnglish
Article number429
JournalF1000Research
Volume7
Publication statusPublished - 6 Apr 2018

Keywords

  • B cell development, B cell differentiation, B cell receptor