Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection

Research output: Contribution to journalArticlepeer-review

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Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection. / Zuo, Jianmin; Dowell, Alexander C; Pearce, Hayden; Verma, Kriti; Long, Heather M; Begum, Jusnara; Aiano, Felicity; Amin-Chowdhury, Zahin; Hallis, Bassam; Stapley, Lorrain; Borrow, Ray; Linley, Ezra; Ahmad, Shazaad; Parker, Ben; Horsley, Alex; Amirthalingam, Gayatri; Brown, Kevin; Ramsay, Mary E; Ladhani, Shamez; Moss, Paul.

In: Nature Immunology, Vol. 22, No. 5, 05.2021, p. 620-626.

Research output: Contribution to journalArticlepeer-review

Harvard

Zuo, J, Dowell, AC, Pearce, H, Verma, K, Long, HM, Begum, J, Aiano, F, Amin-Chowdhury, Z, Hallis, B, Stapley, L, Borrow, R, Linley, E, Ahmad, S, Parker, B, Horsley, A, Amirthalingam, G, Brown, K, Ramsay, ME, Ladhani, S & Moss, P 2021, 'Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection', Nature Immunology, vol. 22, no. 5, pp. 620-626. https://doi.org/10.1038/s41590-021-00902-8

APA

Zuo, J., Dowell, A. C., Pearce, H., Verma, K., Long, H. M., Begum, J., Aiano, F., Amin-Chowdhury, Z., Hallis, B., Stapley, L., Borrow, R., Linley, E., Ahmad, S., Parker, B., Horsley, A., Amirthalingam, G., Brown, K., Ramsay, M. E., Ladhani, S., & Moss, P. (2021). Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection. Nature Immunology, 22(5), 620-626. https://doi.org/10.1038/s41590-021-00902-8

Vancouver

Author

Zuo, Jianmin ; Dowell, Alexander C ; Pearce, Hayden ; Verma, Kriti ; Long, Heather M ; Begum, Jusnara ; Aiano, Felicity ; Amin-Chowdhury, Zahin ; Hallis, Bassam ; Stapley, Lorrain ; Borrow, Ray ; Linley, Ezra ; Ahmad, Shazaad ; Parker, Ben ; Horsley, Alex ; Amirthalingam, Gayatri ; Brown, Kevin ; Ramsay, Mary E ; Ladhani, Shamez ; Moss, Paul. / Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection. In: Nature Immunology. 2021 ; Vol. 22, No. 5. pp. 620-626.

Bibtex

@article{3e6827731a104a9f96b3b4021e02b9a2,
title = "Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection",
abstract = "The immune response to SARS-CoV-2 is critical in controlling disease, but there is concern that waning immunity may predispose to reinfection. We analyzed the magnitude and phenotype of the SARS-CoV-2-specific T cell response in 100 donors at 6 months following infection. T cell responses were present by ELISPOT and/or intracellular cytokine staining analysis in all donors and characterized by predominant CD4+ T cell responses with strong interleukin (IL)-2 cytokine expression. Median T cell responses were 50% higher in donors who had experienced a symptomatic infection, indicating that the severity of primary infection establishes a 'set point' for cellular immunity. T cell responses to spike and nucleoprotein/membrane proteins were correlated with peak antibody levels. Furthermore, higher levels of nucleoprotein-specific T cells were associated with preservation of nucleoprotein-specific antibody level although no such correlation was observed in relation to spike-specific responses. In conclusion, our data are reassuring that functional SARS-CoV-2-specific T cell responses are retained at 6 months following infection.",
keywords = "Adult, Aged, Antibodies, Viral/blood, Antigens, Viral/immunology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, COVID-19/blood, Female, Host-Pathogen Interactions, Humans, Immunity, Cellular, Interleukin-2/blood, Male, Middle Aged, Phenotype, SARS-CoV-2/immunology, Time Factors, Young Adult",
author = "Jianmin Zuo and Dowell, {Alexander C} and Hayden Pearce and Kriti Verma and Long, {Heather M} and Jusnara Begum and Felicity Aiano and Zahin Amin-Chowdhury and Bassam Hallis and Lorrain Stapley and Ray Borrow and Ezra Linley and Shazaad Ahmad and Ben Parker and Alex Horsley and Gayatri Amirthalingam and Kevin Brown and Ramsay, {Mary E} and Shamez Ladhani and Paul Moss",
year = "2021",
month = may,
doi = "10.1038/s41590-021-00902-8",
language = "English",
volume = "22",
pages = "620--626",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Publishing Group",
number = "5",

}

RIS

TY - JOUR

T1 - Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection

AU - Zuo, Jianmin

AU - Dowell, Alexander C

AU - Pearce, Hayden

AU - Verma, Kriti

AU - Long, Heather M

AU - Begum, Jusnara

AU - Aiano, Felicity

AU - Amin-Chowdhury, Zahin

AU - Hallis, Bassam

AU - Stapley, Lorrain

AU - Borrow, Ray

AU - Linley, Ezra

AU - Ahmad, Shazaad

AU - Parker, Ben

AU - Horsley, Alex

AU - Amirthalingam, Gayatri

AU - Brown, Kevin

AU - Ramsay, Mary E

AU - Ladhani, Shamez

AU - Moss, Paul

PY - 2021/5

Y1 - 2021/5

N2 - The immune response to SARS-CoV-2 is critical in controlling disease, but there is concern that waning immunity may predispose to reinfection. We analyzed the magnitude and phenotype of the SARS-CoV-2-specific T cell response in 100 donors at 6 months following infection. T cell responses were present by ELISPOT and/or intracellular cytokine staining analysis in all donors and characterized by predominant CD4+ T cell responses with strong interleukin (IL)-2 cytokine expression. Median T cell responses were 50% higher in donors who had experienced a symptomatic infection, indicating that the severity of primary infection establishes a 'set point' for cellular immunity. T cell responses to spike and nucleoprotein/membrane proteins were correlated with peak antibody levels. Furthermore, higher levels of nucleoprotein-specific T cells were associated with preservation of nucleoprotein-specific antibody level although no such correlation was observed in relation to spike-specific responses. In conclusion, our data are reassuring that functional SARS-CoV-2-specific T cell responses are retained at 6 months following infection.

AB - The immune response to SARS-CoV-2 is critical in controlling disease, but there is concern that waning immunity may predispose to reinfection. We analyzed the magnitude and phenotype of the SARS-CoV-2-specific T cell response in 100 donors at 6 months following infection. T cell responses were present by ELISPOT and/or intracellular cytokine staining analysis in all donors and characterized by predominant CD4+ T cell responses with strong interleukin (IL)-2 cytokine expression. Median T cell responses were 50% higher in donors who had experienced a symptomatic infection, indicating that the severity of primary infection establishes a 'set point' for cellular immunity. T cell responses to spike and nucleoprotein/membrane proteins were correlated with peak antibody levels. Furthermore, higher levels of nucleoprotein-specific T cells were associated with preservation of nucleoprotein-specific antibody level although no such correlation was observed in relation to spike-specific responses. In conclusion, our data are reassuring that functional SARS-CoV-2-specific T cell responses are retained at 6 months following infection.

KW - Adult

KW - Aged

KW - Antibodies, Viral/blood

KW - Antigens, Viral/immunology

KW - CD4-Positive T-Lymphocytes/immunology

KW - CD8-Positive T-Lymphocytes/immunology

KW - COVID-19/blood

KW - Female

KW - Host-Pathogen Interactions

KW - Humans

KW - Immunity, Cellular

KW - Interleukin-2/blood

KW - Male

KW - Middle Aged

KW - Phenotype

KW - SARS-CoV-2/immunology

KW - Time Factors

KW - Young Adult

UR - http://www.scopus.com/inward/record.url?scp=85102168850&partnerID=8YFLogxK

U2 - 10.1038/s41590-021-00902-8

DO - 10.1038/s41590-021-00902-8

M3 - Article

C2 - 33674800

VL - 22

SP - 620

EP - 626

JO - Nature Immunology

JF - Nature Immunology

SN - 1529-2908

IS - 5

ER -