Risk, risk factors and surveillance of subsequent malignant neoplasms in childhood cancer survivors: a review

Research output: Contribution to journalArticlepeer-review

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Risk, risk factors and surveillance of subsequent malignant neoplasms in childhood cancer survivors: a review. / Turcotte, Lucie M. ; Neglia, Joseph P. ; Reulen, Raoul; Ronckers, Cecile M; van Leeuwen, Flora E. ; Morton, Lindsay M. ; Hodgson, David C.; Yasui, Yutaka ; Oeffinger, Kevin C; Henderson, Tara O. .

In: Journal of Clinical Oncology , Vol. 36, 06.06.2018.

Research output: Contribution to journalArticlepeer-review

Harvard

Turcotte, LM, Neglia, JP, Reulen, R, Ronckers, CM, van Leeuwen, FE, Morton, LM, Hodgson, DC, Yasui, Y, Oeffinger, KC & Henderson, TO 2018, 'Risk, risk factors and surveillance of subsequent malignant neoplasms in childhood cancer survivors: a review', Journal of Clinical Oncology , vol. 36. https://doi.org/10.1200/JCO.2017.76.7764

APA

Turcotte, L. M., Neglia, J. P., Reulen, R., Ronckers, C. M., van Leeuwen, F. E., Morton, L. M., Hodgson, D. C., Yasui, Y., Oeffinger, K. C., & Henderson, T. O. (2018). Risk, risk factors and surveillance of subsequent malignant neoplasms in childhood cancer survivors: a review. Journal of Clinical Oncology , 36. https://doi.org/10.1200/JCO.2017.76.7764

Vancouver

Author

Turcotte, Lucie M. ; Neglia, Joseph P. ; Reulen, Raoul ; Ronckers, Cecile M ; van Leeuwen, Flora E. ; Morton, Lindsay M. ; Hodgson, David C. ; Yasui, Yutaka ; Oeffinger, Kevin C ; Henderson, Tara O. . / Risk, risk factors and surveillance of subsequent malignant neoplasms in childhood cancer survivors: a review. In: Journal of Clinical Oncology . 2018 ; Vol. 36.

Bibtex

@article{f7374f0bbbef4cd0961c058f46134606,
title = "Risk, risk factors and surveillance of subsequent malignant neoplasms in childhood cancer survivors: a review",
abstract = "Subsequent malignant neoplasms (SMNs) in childhood cancer survivors cause substantial morbidity and mortality. This review summarizes recent literature on SMN epidemiology, risk factors, surveillance, and interventions. Childhood cancer survivors experience long-term increased SMN risk compared to the general population, with more than 2-fold increased solid tumor risk extending beyond age 40 years. There is a dose-dependent increased risk for solid tumors following radiotherapy, with the highest risks for tumors occurring in or near the treatment field (e.g., >5-fold increased risk for breast, brain, thyroid, skin, bone, and soft-tissue malignancies). Alkylating and anthracycline chemotherapy increase the risk of several solid malignancies in addition to acute leukemia/myelodysplasia and these risks may be modified by other patient characteristics, such as age at exposure and, potentially, inherited genetic susceptibility. Strategies for identifying survivors at risk and initiating long-term surveillance have improved and interventions are underway to improve knowledge about late-treatment effects among survivors and caregivers. Better understanding of treatment-related risk factors and genetic susceptibility holds promise for refining surveillance strategies, and ultimately upfront cancer therapies.",
author = "Turcotte, {Lucie M.} and Neglia, {Joseph P.} and Raoul Reulen and Ronckers, {Cecile M} and {van Leeuwen}, {Flora E.} and Morton, {Lindsay M.} and Hodgson, {David C.} and Yutaka Yasui and Oeffinger, {Kevin C} and Henderson, {Tara O.}",
year = "2018",
month = jun,
day = "6",
doi = "10.1200/JCO.2017.76.7764",
language = "English",
volume = "36",
journal = "Journal of Clinical Oncology ",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",

}

RIS

TY - JOUR

T1 - Risk, risk factors and surveillance of subsequent malignant neoplasms in childhood cancer survivors: a review

AU - Turcotte, Lucie M.

AU - Neglia, Joseph P.

AU - Reulen, Raoul

AU - Ronckers, Cecile M

AU - van Leeuwen, Flora E.

AU - Morton, Lindsay M.

AU - Hodgson, David C.

AU - Yasui, Yutaka

AU - Oeffinger, Kevin C

AU - Henderson, Tara O.

PY - 2018/6/6

Y1 - 2018/6/6

N2 - Subsequent malignant neoplasms (SMNs) in childhood cancer survivors cause substantial morbidity and mortality. This review summarizes recent literature on SMN epidemiology, risk factors, surveillance, and interventions. Childhood cancer survivors experience long-term increased SMN risk compared to the general population, with more than 2-fold increased solid tumor risk extending beyond age 40 years. There is a dose-dependent increased risk for solid tumors following radiotherapy, with the highest risks for tumors occurring in or near the treatment field (e.g., >5-fold increased risk for breast, brain, thyroid, skin, bone, and soft-tissue malignancies). Alkylating and anthracycline chemotherapy increase the risk of several solid malignancies in addition to acute leukemia/myelodysplasia and these risks may be modified by other patient characteristics, such as age at exposure and, potentially, inherited genetic susceptibility. Strategies for identifying survivors at risk and initiating long-term surveillance have improved and interventions are underway to improve knowledge about late-treatment effects among survivors and caregivers. Better understanding of treatment-related risk factors and genetic susceptibility holds promise for refining surveillance strategies, and ultimately upfront cancer therapies.

AB - Subsequent malignant neoplasms (SMNs) in childhood cancer survivors cause substantial morbidity and mortality. This review summarizes recent literature on SMN epidemiology, risk factors, surveillance, and interventions. Childhood cancer survivors experience long-term increased SMN risk compared to the general population, with more than 2-fold increased solid tumor risk extending beyond age 40 years. There is a dose-dependent increased risk for solid tumors following radiotherapy, with the highest risks for tumors occurring in or near the treatment field (e.g., >5-fold increased risk for breast, brain, thyroid, skin, bone, and soft-tissue malignancies). Alkylating and anthracycline chemotherapy increase the risk of several solid malignancies in addition to acute leukemia/myelodysplasia and these risks may be modified by other patient characteristics, such as age at exposure and, potentially, inherited genetic susceptibility. Strategies for identifying survivors at risk and initiating long-term surveillance have improved and interventions are underway to improve knowledge about late-treatment effects among survivors and caregivers. Better understanding of treatment-related risk factors and genetic susceptibility holds promise for refining surveillance strategies, and ultimately upfront cancer therapies.

U2 - 10.1200/JCO.2017.76.7764

DO - 10.1200/JCO.2017.76.7764

M3 - Article

VL - 36

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

ER -